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    lsr2 iron-regulated H-NS-like protein [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885580, updated on 12-Feb-2021

    Summary

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    Gene symbol
    lsr2
    Gene description
    iron-regulated H-NS-like protein
    Locus tag
    Rv3597c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (4040981..4041319, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene PE-PGRS family protein PE_PGRS59 Neighboring gene ATP-dependent protease ATP-binding subunit ClpC Neighboring gene lysine--tRNA ligase Neighboring gene type III pantothenate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of DNA organization by Mycobacterium tuberculosis protein Lsr2. Qu Y, et al. Nucleic Acids Res, 2013 May 1. PMID 23580555, Free PMC Article
    2. Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis. Gordon BR, et al. Proc Natl Acad Sci U S A, 2010 Mar 16. PMID 20133735, Free PMC Article
    3. The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates. Colangeli R, et al. Proc Natl Acad Sci U S A, 2009 Mar 17. PMID 19237572, Free PMC Article
    4. The mycobacterial iron-dependent regulator IdeR induces ferritin (bfrB) by alleviating Lsr2 repression. Kurthkoti K, et al. Mol Microbiol, 2015 Dec. PMID 26268801, Free PMC Article
    5. Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins. Gordon BR, et al. J Bacteriol, 2008 Nov. PMID 18776007, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results elucidate the main mechanism of bfrB positive regulation by IdeR and identify Lsr2 as a new factor contributing to Fe homeostasis in mycobacteria.
      Title: The mycobacterial iron-dependent regulator IdeR induces ferritin (bfrB) by alleviating Lsr2 repression.
    2. This report shows that Lsr2 cooperatively binds to DNA forming a rigid Lsr2 nucleoprotein complex that restricts DNA accessibility, similar to H-NS.
      Title: Mechanism of DNA organization by Mycobacterium tuberculosis protein Lsr2.
    3. Lsr2 of Mycobacterium tuberculosis is a unique nucleoid-associated protein that binds AT-rich regions of the genome.
      Title: Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis.
    4. Lsr2 shields DNA from reactive intermediates by binding bacterial DNA and physically protecting it
      Title: The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates.
    5. The results demonstrate unequivocally that Lsr2 is an H-NS-like protein.
      Title: Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    iron-regulated H-NS-like protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      4040981..4041319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_218114.1 iron-regulated H-NS-like protein [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_218114.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P9WIP7
      UniProtKB/TrEMBL
      I6X7R6
      Conserved Domains (1) summary
      pfam11774
      Location:1 → 111
      Lsr2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WIP7.1

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