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    FHIP2B FHF complex subunit HOOK interacting protein 2B [ Homo sapiens (human) ]

    Gene ID: 64760, updated on 17-Sep-2024

    Summary

    Official Symbol
    FHIP2Bprovided by HGNC
    Official Full Name
    FHF complex subunit HOOK interacting protein 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:16492
    See related
    Ensembl:ENSG00000158863 MIM:620230; AllianceGenome:HGNC:16492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAI16; RAI16; FAM160B2; RAM160B2
    Expression
    Ubiquitous expression in skin (RPKM 11.2), prostate (RPKM 9.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FHIP2B in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22089150..22104911)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22363108..22378867)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21946661..21962422)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903342-21903848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903849-21904354 Neighboring gene fibroblast growth factor 17 Neighboring gene VISTA enhancer hs781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21908959-21909751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21915443-21916404 Neighboring gene dematin actin binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21917368-21918329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21943692-21944301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21951526-21952026 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:21961808-21961955 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 8:21964802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21965271-21966044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21969459-21969958 Neighboring gene nudix hydrolase 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21972531-21973193 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:21977874-21978076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21978415-21978914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21981891-21982392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21982393-21982892 Neighboring gene HR lysine demethylase and nuclear receptor corepressor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21987125-21987702 Neighboring gene HR upstream open reading frame

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11125, FLJ21801, MGC138352

    General protein information

    Preferred Names
    FHF complex subunit HOOK-interacting protein 2B
    Names
    family with sequence similarity 160 member B2
    protein FAM160B2
    retinoic acid induced 16
    retinoic acid-induced protein 16

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354250.2NP_001341179.1  FHF complex subunit HOOK-interacting protein 2B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC091171
      Conserved Domains (1) summary
      pfam10257
      Location:79475
      RAI16-like; Retinoic acid induced 16-like protein
    2. NM_001354251.2NP_001341180.1  FHF complex subunit HOOK-interacting protein 2B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC091171
      Conserved Domains (1) summary
      pfam10257
      Location:21418
      RAI16-like; Retinoic acid induced 16-like protein
    3. NM_022749.7NP_073586.5  FHF complex subunit HOOK-interacting protein 2B isoform 1

      See identical proteins and their annotated locations for NP_073586.5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC091171
      Consensus CDS
      CCDS6021.2
      UniProtKB/Swiss-Prot
      B2RDQ5, B3KNX1, Q2M211, Q71JB5, Q7L3J6, Q86V87, Q969T0, Q9H6W4
      Related
      ENSP00000289921.6, ENST00000289921.8
      Conserved Domains (1) summary
      pfam10257
      Location:79476
      RAI16-like; Retinoic acid induced 16-like protein

    RNA

    1. NR_148727.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171, BC052237, HY033313
    2. NR_148728.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171
    3. NR_148729.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171
    4. NR_148730.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171
    5. NR_148731.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      22089150..22104911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006716381.4XP_006716444.1  FHF complex subunit HOOK-interacting protein 2B isoform X1

      Conserved Domains (1) summary
      pfam10257
      Location:79476
      RAI16-like; Retinoic acid induced 16-like protein
    2. XM_005273602.5XP_005273659.1  FHF complex subunit HOOK-interacting protein 2B isoform X2

      See identical proteins and their annotated locations for XP_005273659.1

      Conserved Domains (1) summary
      pfam10257
      Location:79476
      RAI16-like; Retinoic acid induced 16-like protein

    RNA

    1. XR_007060751.1 RNA Sequence

    2. XR_428314.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      22363108..22378867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361015.1XP_054216990.1  FHF complex subunit HOOK-interacting protein 2B isoform X1

    2. XM_054361016.1XP_054216991.1  FHF complex subunit HOOK-interacting protein 2B isoform X2

    RNA

    1. XR_008487870.1 RNA Sequence

    2. XR_008487871.1 RNA Sequence