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    Bzw1 basic leucine zipper and W2 domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 66882, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bzw1provided by MGI
    Official Full Name
    basic leucine zipper and W2 domains 1provided by MGI
    Primary source
    MGI:MGI:1914132
    See related
    Ensembl:ENSMUSG00000051223 AllianceGenome:MGI:1914132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0005; 1200015E15Rik
    Summary
    Predicted to be involved in regulation of translational initiation. Predicted to be active in cytoplasm. Is expressed in early conceptus. Orthologous to human BZW1 (basic leucine zipper and W2 domains 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 69.8), CNS E18 (RPKM 52.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bzw1 in Genome Data Viewer
    Location:
    1 C1.3; 1 29.09 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58432057..58446513)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58392898..58407354)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene aldehyde oxidase 2 Neighboring gene predicted gene 15759 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58450605-58450792 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 53481 Neighboring gene STARR-seq mESC enhancer starr_01013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58480276-58480459 Neighboring gene STARR-positive B cell enhancer ABC_E5756 Neighboring gene CDC-like kinase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58501960-58502147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58502340-58502523 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 3 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alternative 3' UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression. Yu M, et al. Biochem Biophys Res Commun, 2006 Jun 23. PMID 16690031
    2. Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation. Zhang J, et al. Nat Commun, 2022 Nov 4. PMID 36333315, Free PMC Article
    3. Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. Qi H, et al. Cell Mol Biol Lett, 2023 Oct 12. PMID 37828427, Free PMC Article
    4. Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration. Shen ZJ, et al. Cells, 2021 Jan 21. PMID 33494375, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
      Title: Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
    2. Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.
      Title: Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6434

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eIF5-mimic protein 2
    Names
    basic leucine zipper and W2 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025824.4 → NP_080100.1  eIF5-mimic protein 2

      See identical proteins and their annotated locations for NP_080100.1

      Status: VALIDATED

      Source sequence(s)
      AC121091, AK076560, AK161192, CJ085444
      Consensus CDS
      CCDS14971.1
      UniProtKB/Swiss-Prot
      Q3THS5, Q3UZ94, Q9CQC6
      Related
      ENSMUSP00000051935.9, ENSMUST00000050552.15
      Conserved Domains (1) summary
      cd11560
      Location:217 → 406
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58432057..58446513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322066.1 → XP_017177555.1  eIF5-mimic protein 2 isoform X1

      Conserved Domains (1) summary
      cd11560
      Location:133 → 322
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQC6.1 GenPept UniProtKB/Swiss-Prot:Q9CQC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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