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    PCLAF PCNA clamp associated factor [ Homo sapiens (human) ]

    Gene ID: 9768, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PCLAFprovided by HGNC
    Official Full Name
    PCNA clamp associated factorprovided by HGNC
    Primary source
    HGNC:HGNC:28961
    See related
    Ensembl:ENSG00000166803 MIM:610696; AllianceGenome:HGNC:28961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L5; PAF; OEATC; PAF15; OEATC1; p15PAF; NS5ATP9; OEATC-1; p15/PAF; KIAA0101; p15(PAF)
    Summary
    Enables chromatin binding activity and molecular adaptor activity. Involved in several processes, including DNA metabolic process; centrosome cycle; and response to UV. Located in centrosome; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bone marrow (RPKM 26.4), lymph node (RPKM 13.8) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PCLAF in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (64364304..64387687, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62173847..62197108, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64656503..64679886, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64453780-64454344 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64454578-64455078 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64455079-64455579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9565 Neighboring gene casein kinase 1 gamma 1 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64538178-64538678 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64538679-64539179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9566 Neighboring gene Sharpr-MPRA regulatory region 12494 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64618290-64619150 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64619151-64620010 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6533 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64652953-64653179 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64673301-64673811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64679750-64680250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64680251-64680751 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722213-64722724 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722725-64723236 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:64736443-64737642 Neighboring gene uncharacterized LOC105370861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9569 Neighboring gene zinc finger protein 609 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64803884-64804071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64820886-64821752 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 61

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Elevated KIAA0101 expression is a marker of recurrence in human gastric cancer. Zhu K, et al. Cancer Sci, 2013 Mar. PMID 23240630, Free PMC Article
    2. PAF enhances cancer stem cell properties via β-catenin signaling in hepatocellular carcinoma. Li M, et al. Cell Cycle, 2021 May. PMID 33970778, Free PMC Article
    3. [Functional prediction of KIAA0101 gene in human non-small cell lung cancer]. Li H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2010 Jan. PMID 20118010
    4. PCNA-associated factor (KIAA0101/PCLAF) overexpression and gene copy number alterations in hepatocellular carcinoma tissues. Tantiwetrueangdet A, et al. BMC Cancer, 2021 Mar 20. PMID 33743635, Free PMC Article
    5. Paf15 expression correlates with rectal cancer prognosis, cell proliferation and radiation response. Yan R, et al. Oncotarget, 2016 Jun 21. PMID 27246972, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of LINC01138 protects human chondrocytes against IL-1beta-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis.
      Title: Knockdown of LINC01138 protects human chondrocytes against IL-1β-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis.
    2. KIAA0101 and IL2RA Were Identified as Core Genes in Hormone-Resistant Nephropathy.
      Title: KIAA0101 and IL2RA Were Identified as Core Genes in Hormone-Resistant Nephropathy.
    3. KIAA0101 in Malignant Pleural Mesothelioma: A Potential Diagnostic and Prognostic Marker.
      Title: KIAA0101 in Malignant Pleural Mesothelioma: A Potential Diagnostic and Prognostic Marker.
    4. PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis.
      Title: PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis.
    5. Circ_0005231 promotes the progression of esophageal squamous cell carcinoma via sponging miR-383-5p and regulating KIAA0101.
      Title: Circ_0005231 promotes the progression of esophageal squamous cell carcinoma via sponging miR-383-5p and regulating KIAA0101.
    6. KIAA0101 knockdown inhibits glioma progression and glycolysis by inactivating the PI3K/AKT/mTOR pathway.
      Title: KIAA0101 knockdown inhibits glioma progression and glycolysis by inactivating the PI3K/AKT/mTOR pathway.
    7. PAF enhances cancer stem cell properties via beta-catenin signaling in hepatocellular carcinoma.
      Title: PAF enhances cancer stem cell properties via β-catenin signaling in hepatocellular carcinoma.
    8. Circular RNA TADA2A promotes proliferation and migration via modulating of miR638/KIAA0101 signal in nonsmall cell lung cancer.
      Title: Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer.
    9. KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma.
      Title: KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma.
    10. MicroRNA216a5p suppresses esophageal squamous cell carcinoma progression by targeting KIAA0101.
      Title: MicroRNA‑216a‑5p suppresses esophageal squamous cell carcinoma progression by targeting KIAA0101.
    Submit: New GeneRIF Correction See all GeneRIFs (62)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ58702, KIAA0101

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PCNA-associated factor
    Names
    HCV NS5A-transactivated protein 9
    PCNA-associated factor of 15 kDa
    hepatitis C virus NS5A-transactivated protein 9
    overexpressed in anaplastic thyroid carcinoma 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029989.3 → NP_001025160.1  PCNA-associated factor isoform 2

      See identical proteins and their annotated locations for NP_001025160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC087632, AV757440, BC005832
      Consensus CDS
      CCDS32269.1
      UniProtKB/Swiss-Prot
      Q15004
      Related
      ENSP00000369608.2, ENST00000380258.6
      Conserved Domains (1) summary
      pfam15715
      Location:1 → 27
      PAF; PCNA-associated factor

    2. NM_014736.6 → NP_055551.1  PCNA-associated factor isoform 1

      See identical proteins and their annotated locations for NP_055551.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC087632, BC005832, BF691807
      Consensus CDS
      CCDS10193.1
      UniProtKB/Swiss-Prot
      A6NNU5, A8K3Y3, G9G694, G9G696, Q15004
      UniProtKB/TrEMBL
      A0A024R5W5, H0YMA4
      Related
      ENSP00000300035.4, ENST00000300035.9
      Conserved Domains (1) summary
      pfam15715
      Location:1 → 74
      PAF; PCNA-associated factor

    RNA

    1. NR_109934.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC087632, BC005832, DT220867

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      64364304..64387687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      62173847..62197108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15004.1 GenPept UniProtKB/Swiss-Prot:Q15004

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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