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    Caskin2 CASK-interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 140721, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Caskin2provided by MGI
    Official Full Name
    CASK-interacting protein 2provided by MGI
    Primary source
    MGI:MGI:2157062
    See related
    Ensembl:ENSMUSG00000034471 AllianceGenome:MGI:2157062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1139; 1600028L06Rik
    Summary
    Predicted to be located in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human CASKIN2 (CASK interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 50.9), lung adult (RPKM 48.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Caskin2 in Genome Data Viewer
    Location:
    11 E2; 11 80.91 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115689813..115704517, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115798987..115813658, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 94 Neighboring gene predicted gene, 46302 Neighboring gene microRNA 5621 Neighboring gene STARR-positive B cell enhancer ABC_E3039 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene STARR-seq mESC enhancer starr_31175 Neighboring gene LLGL2 scribble cell polarity complex component Neighboring gene STARR-seq mESC enhancer starr_31178

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins. Bencsik N, et al. Sci Rep, 2019 Nov 14. PMID 31727973, Free PMC Article
    2. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein. Tabuchi K, et al. J Neurosci, 2002 Jun 1. PMID 12040031, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
      Title: Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    caskin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080643.2 → NP_542374.2  caskin-2

      Status: VALIDATED

      Source sequence(s)
      BC053083
      Consensus CDS
      CCDS25647.1
      UniProtKB/Swiss-Prot
      B1ATA2, Q6ZPX1, Q7TS77, Q8VHK1
      Related
      ENSMUSP00000041328.5, ENSMUST00000041684.11
      Conserved Domains (10) summary
      cd09497
      Location:487 → 552
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:553 → 623
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:561 → 620
      SAM; Sterile alpha motif
      cd12063
      Location:284 → 345
      SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
      cd00204
      Location:76 → 209
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:152 → 251
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:7 → 61
      Ank_4; Ankyrin repeats (many copies)
      pfam16632
      Location:1144 → 1201
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:797 → 881
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:114 → 145
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115689813..115704517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248719.4 → XP_011247021.1  caskin-2 isoform X3

      Conserved Domains (9) summary
      cd09497
      Location:355 → 420
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:421 → 491
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      cd12063
      Location:152 → 213
      SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
      PHA03247
      Location:529 → 975
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:18 → 54
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:20 → 119
      Ank_2; Ankyrin repeats (3 copies)
      pfam16600
      Location:266 → 293
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:1012 → 1069
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:665 → 749
      Caskin-Pro-rich; Proline rich region of Caskin proteins

    2. XM_030245554.2 → XP_030101414.1  caskin-2 isoform X2

      Conserved Domains (9) summary
      cd09497
      Location:405 → 470
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:471 → 541
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      cd12063
      Location:202 → 263
      SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
      PHA03247
      Location:579 → 1025
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:32 → 63
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:70 → 169
      Ank_2; Ankyrin repeats (3 copies)
      pfam16600
      Location:316 → 343
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:1062 → 1119
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:715 → 799
      Caskin-Pro-rich; Proline rich region of Caskin proteins

    3. XM_030245555.2 → XP_030101415.1  caskin-2 isoform X3

      Conserved Domains (9) summary
      cd09497
      Location:355 → 420
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:421 → 491
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      cd12063
      Location:152 → 213
      SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
      PHA03247
      Location:529 → 975
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:18 → 54
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:20 → 119
      Ank_2; Ankyrin repeats (3 copies)
      pfam16600
      Location:266 → 293
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:1012 → 1069
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:665 → 749
      Caskin-Pro-rich; Proline rich region of Caskin proteins

    4. XM_006532181.5 → XP_006532244.1  caskin-2 isoform X1

      Conserved Domains (10) summary
      cd09497
      Location:466 → 531
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:532 → 602
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      cd12063
      Location:263 → 324
      SH3_Caskin2; Src Homology 3 domain of CASK interacting protein 2
      PHA03247
      Location:640 → 1086
      PHA03247; large tegument protein UL36; Provisional
      COG0666
      Location:57 → 192
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:93 → 124
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:131 → 230
      Ank_2; Ankyrin repeats (3 copies)
      pfam16600
      Location:377 → 404
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:1123 → 1180
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:776 → 860
      Caskin-Pro-rich; Proline rich region of Caskin proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHK1.3 GenPept UniProtKB/Swiss-Prot:Q8VHK1

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