slc9a7 solute carrier family 9 member 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc9a7provided by ZNC
Official Full Name: solute carrier family 9 member 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-8
See related: Ensembl:ENSDARG00000076754 AllianceGenome:ZFIN:ZDB-GENE-050913-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NHE7; wu:fk03b09; zgc:101088; zgc:113878
Summary: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within proton transmembrane transport; regulation of pH; and sodium ion transport. Predicted to be located in recycling endosome membrane. Predicted to be active in plasma membrane and recycling endosome. Is expressed in female organism; gill; and testis. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 108. Orthologous to human SLC9A7 (solute carrier family 9 member A7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (37529383..37600648)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (37551489..37622754)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of pH	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium/hydrogen exchanger 7

Names: solute carrier family 9 (sodium/hydrogen exchanger), member 7; solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030077.2 → NP_001025248.2 sodium/hydrogen exchanger 7

Status: VALIDATED

Source sequence(s)

BC165247, BX322552, EF591987

UniProtKB/TrEMBL

A0A8M1N7F8, A9XPA4, F1QI95

Related

ENSDARP00000039933.6, ENSDART00000039934.8

Conserved Domains (1) summary

pfam00999
Location:165 → 523

Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

37529383..37600648

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165986.5 → XP_005166043.1 sodium/hydrogen exchanger 7 isoform X1

UniProtKB/TrEMBL

A0A8M2BDB4, A9XPA4

Conserved Domains (1) summary

pfam00999
Location:165 → 523

Na_H_Exchanger; Sodium/hydrogen exchanger family