nots nothepsin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: notsprovided by ZNC
Official Full Name: nothepsinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010620-1
See related: Ensembl:ENSDARG00000099824 AllianceGenome:ZFIN:ZDB-GENE-010620-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: LAP; ctsel; zgc:103608
Summary: Predicted to enable aspartic-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Is expressed in liver. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (78010696..78020284, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_008805374.1 (6656..16932)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nothepsin

Names: aspartic proteinase

NP_571879.1

EC 3.4.23.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131804.1 → NP_571879.1 nothepsin

See identical proteins and their annotated locations for NP_571879.1

Status: PROVISIONAL

Source sequence(s)

AJ278269

UniProtKB/TrEMBL

Q9DDE2

Related

ENSDARP00000130638.2, ENSDART00000159559.2

Conserved Domains (3) summary

pfam00026
Location:85 → 403

Asp; Eukaryotic aspartyl protease

pfam07966
Location:20 → 48

A1_Propeptide; A1 Propeptide

cl11403
Location:86 → 403

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases