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    irf7 interferon regulatory factor 7 [ Danio rerio (zebrafish) ]

    Gene ID: 393650, updated on 2-Nov-2024

    Summary

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    Official Symbol
    irf7provided by ZNC
    Official Full Name
    interferon regulatory factor 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1518
    See related
    Ensembl:ENSDARG00000045661 AllianceGenome:ZFIN:ZDB-GENE-040426-1518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66043; zgc:77947; wu:fl24c03
    Summary
    Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including negative regulation of hematopoietic stem cell differentiation; neuromast hair cell development; and response to virus. Located in cytoplasm. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; digestive system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See irf7 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (25546789..25550944, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (25451711..25455866, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489363 Neighboring gene microRNA 210 Neighboring gene PHD and ring finger domains 1 Neighboring gene hypermethylated in cancer 1 like Neighboring gene TBC1 domain family, member 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7. Zhou CJ, et al. Dev Comp Immunol, 2024 Jul. PMID 38636698
    2. Characteristics of the interferon regulatory factor pairs zfIRF5/7 and their stimulation expression by ISKNV Infection in zebrafish (Danio rerio). Xiang Z, et al. Dev Comp Immunol, 2010 Dec. PMID 20637800
    3. Behavioural fever in zebrafish larvae. Rey S, et al. Dev Comp Immunol, 2017 Feb. PMID 27670815
    4. PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish. Zhao X, et al. Front Immunol, 2022. PMID 36172355, Free PMC Article
    5. Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis. Hu SQ, et al. Dev Neurobiol, 2022 Jan. PMID 34779143, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7.
      Title: Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7.
    2. Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway.
      Title: Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway.
    3. Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis.
      Title: Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis.
    4. Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7.
      Title: Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7.
    5. Following spring viremia of carp virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp virus. data provide evidence that fish and mammals have evolved a similar IRF-dependent regulatory mechanism fine-tuning IFN gene activation.
      Title: Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNΦ1 and IFNΦ3 Expression through Assembly of Homo- or Heteroprotein Complexes.
    6. Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7
      Title: Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7.
    7. The miR-142a-3p regulates HSC formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling.
      Title: miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66043

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transcription regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hemopoiesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of hematopoietic stem cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuromast hair cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon regulatory factor 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313779.1 → NP_001300708.1  interferon regulatory factor 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in its 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL928892, EH494710, EH521037
      UniProtKB/TrEMBL
      A0A8M1P7R4, H0WFC4
      Related
      ENSDARP00000125556.1, ENSDART00000150412.3
      Conserved Domains (2) summary
      pfam00605
      Location:9 → 108
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:171 → 343
      IRF-3; Interferon-regulatory factor 3

    2. NM_200677.2 → NP_956971.2  interferon regulatory factor 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
      Source sequence(s)
      AL928892, EH494710, EH521037
      UniProtKB/TrEMBL
      A0A8M1PFL5, F1QNG2
      Related
      ENSDARP00000094398.3, ENSDART00000103622.5
      Conserved Domains (2) summary
      pfam00605
      Location:9 → 108
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:216 → 388
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      25546789..25550944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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