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    Gpr161 G protein-coupled receptor 161 [ Mus musculus (house mouse) ]

    Gene ID: 240888, updated on 14-Nov-2024

    Summary

    Official Symbol
    Gpr161provided by MGI
    Official Full Name
    G protein-coupled receptor 161provided by MGI
    Primary source
    MGI:MGI:2685054
    See related
    Ensembl:ENSMUSG00000040836 AllianceGenome:MGI:2685054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    vl; Gm208; Gm208Gpr
    Summary
    Enables G protein-coupled receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Located in several cellular components, including cilium; glial cell projection; and recycling endosome. Is expressed in several structures, including central nervous system; eye; and limb. Human ortholog(s) of this gene implicated in medulloblastoma. Orthologous to human GPR161 (G protein-coupled receptor 161). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 9.4), CNS E18 (RPKM 9.0) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gpr161 in Genome Data Viewer
    Location:
    1 H2.2; 1 72.64 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165108760..165154314)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165281184..165326747)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene T-box 19 Neighboring gene STARR-seq mESC enhancer starr_02894 Neighboring gene SFT2 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_02896 Neighboring gene TIP41, TOR signalling pathway regulator-like (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_02898 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene STARR-seq mESC enhancer starr_02900 Neighboring gene STARR-positive B cell enhancer ABC_E2016 Neighboring gene STARR-positive B cell enhancer ABC_E119 Neighboring gene predicted gene, 24637 Neighboring gene mitochondrial pyruvate carrier 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    vacuolated lens
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Spontaneous (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    G-protein coupled receptor 161

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081126.2NP_001074595.1  G-protein coupled receptor 161 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC116374, AK145635, BE991962, BY731738, CN721893
      UniProtKB/Swiss-Prot
      B2RPY5
      Conserved Domains (2) summary
      pfam00001
      Location:73353
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:64270
      7tm_4; Olfactory receptor
    2. NM_001310429.1NP_001297358.1  G-protein coupled receptor 161 isoform 2

      See identical proteins and their annotated locations for NP_001297358.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC116374, BC137659, BE991962, BY731738, CN721893
      Consensus CDS
      CCDS83621.1
      UniProtKB/Swiss-Prot
      B0L0L8, B2RPY5, J3QN69, Q80T48
      Related
      ENSMUSP00000136621.3, ENSMUST00000178700.8
      Conserved Domains (2) summary
      pfam00001
      Location:60340
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:51257
      7tm_4; Olfactory receptor
    3. NM_001310430.1NP_001297359.1  G-protein coupled receptor 161 isoform 3

      See identical proteins and their annotated locations for NP_001297359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC116374, AK145635, BE991962
      Consensus CDS
      CCDS78732.1
      UniProtKB/TrEMBL
      A0A140T8Q9
      Related
      ENSMUSP00000107077.3, ENSMUST00000111450.3
      Conserved Domains (1) summary
      cd15214
      Location:28334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165108760..165154314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496851.5XP_006496914.1  G-protein coupled receptor 161 isoform X1

      See identical proteins and their annotated locations for XP_006496914.1

      UniProtKB/TrEMBL
      A0A140T8Q9
      Conserved Domains (1) summary
      cd15214
      Location:28334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_011238821.4XP_011237123.1  G-protein coupled receptor 161 isoform X1

      See identical proteins and their annotated locations for XP_011237123.1

      UniProtKB/TrEMBL
      A0A140T8Q9
      Conserved Domains (1) summary
      cd15214
      Location:28334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_006496850.5XP_006496913.1  G-protein coupled receptor 161 isoform X1

      See identical proteins and their annotated locations for XP_006496913.1

      UniProtKB/TrEMBL
      A0A140T8Q9
      Conserved Domains (1) summary
      cd15214
      Location:28334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. XM_006496852.5XP_006496915.1  G-protein coupled receptor 161 isoform X1

      See identical proteins and their annotated locations for XP_006496915.1

      UniProtKB/TrEMBL
      A0A140T8Q9
      Conserved Domains (1) summary
      cd15214
      Location:28334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors