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    ZGLP1 zinc finger GATA like protein 1 [ Homo sapiens (human) ]

    Gene ID: 100125288, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZGLP1provided by HGNC
    Official Full Name
    zinc finger GATA like protein 1provided by HGNC
    Primary source
    HGNC:HGNC:37245
    See related
    Ensembl:ENSG00000220201 MIM:611639; AllianceGenome:HGNC:37245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLP1; GLP-1; GATAD3
    Summary
    ZGLP1 encodes an evolutionary conserved transcriptional regulator with GATA-like zinc fingers. In females, it is expressed in embryonic germ cells and is essential for oogenic fate determination. It acts downstream of bone morphogenetic protein (BMP) and is involved in the regulation of genes involved in RNA processing, transcription and chromatin modification, retrotransposon regulation, meiotic cell cycle, and oocyte development. In males it is not required for the germ cell sex determination but is required by the spermatogonia for efficiently completing the meiotic prophase. [provided by RefSeq, Jul 2022]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Ubiquitous expression in testis (RPKM 1.4), spleen (RPKM 0.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZGLP1 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10304803..10309815, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10430915..10435928, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10415479..10420491, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10397303-10398272 Neighboring gene ICAM4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10062 Neighboring gene intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10402483-10403475 Neighboring gene intercellular adhesion molecule 5 Neighboring gene CRISPRi-validated cis-regulatory element chr19.1775 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:10415538-10416737 Neighboring gene FDX2-ZGLP1 readthrough Neighboring gene ferredoxin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10064 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10427579-10427770 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10430834-10431047 Neighboring gene ribonucleoprotein, PTB binding 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10442682-10443598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10443599-10444515

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men. Matikainen N, et al. PLoS One, 2016. PMID 26752550, Free PMC Article
    2. GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development. Li S, et al. Dev Biol, 2007 Jan 1. PMID 16982049, Free PMC Article
    3. ZGLP1 is a determinant for the oogenic fate in mice. Nagaoka SI, et al. Science, 2020 Mar 6. PMID 32054698
    4. Whole-genome sequencing reveals host factors underlying critical COVID-19. Kousathanas A, et al. Nature, 2022 Jul. PMID 35255492, Free PMC Article
    5. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There is minor contribution of endogenous GLP-1 and GLP-2 to postprandial lipemia in obese men.
      Title: Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men.
    2. Characterization and functional analysis of the mouse GLP-1 ortholog, and comparison to the human protein.
      Title: GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Readthrough FDX2-ZGLP1

    Readthrough gene: FDX2-ZGLP1, Included gene: FDX2

    Homology

    Clone Names

    • FLJ39511, FLJ39703

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oocyte development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GATA-type zinc finger protein 1
    Names
    GATA zinc finger domain containing 3
    GATA-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103167.1 → NP_001096637.1  GATA-type zinc finger protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001096637.1

      Status: VALIDATED

      Source sequence(s)
      BC029904, CK826281
      Consensus CDS
      CCDS45959.1
      Conserved Domains (2) summary
      smart00401
      Location:202 → 240
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      pfam00320
      Location:206 → 240
      GATA; GATA zinc finger

    2. NM_001409033.1 → NP_001395962.1  GATA-type zinc finger protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC011511
      UniProtKB/Swiss-Prot
      A0A9L9PXT6, P0C6A0
      Related
      ENSP00000516709.1, ENST00000707000.1

    RNA

    1. NR_176053.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC011511
      Related
      ENST00000480726.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10304803..10309815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10430915..10435928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C6A0.2 GenPept UniProtKB/Swiss-Prot:P0C6A0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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