LILRA4 leukocyte immunoglobulin like receptor A4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LILRA4provided by HGNC
Official Full Name: leukocyte immunoglobulin like receptor A4provided by HGNC
Primary source: HGNC:HGNC:15503
See related: Ensembl:ENSG00000239961 MIM:607517; AllianceGenome:HGNC:15503
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ILT7; CD85g
Summary: This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]
Expression: Biased expression in spleen (RPKM 5.0), lymph node (RPKM 4.4) and 6 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (54333185..54339162, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (57422956..57428933, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (54844456..54850433, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crosslinked ILT7 favours the differentiation of immature plasmacytoid dendritic cells into antigen-presenting cells rather than IPC.
Title: Effect of immunoglobin-like transcript 7 cross-linking on plasmacytoid dendritic cells differentiation into antigen-presenting cells.
ILT7 may exert its immunomodulatory activity only on immature circulating plasmacytoid dendritic cells (pDCs), providing a basic homeostatic mechanism rather than negative feedback control on activated pDCs.
Title: Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes.
Intracellular expression of the TCL1 as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were tested.
Title: Intracytoplasmic detection of TCL1--but not ILT7-by flow cytometry is useful for blastic plasmacytoid dendritic cell leukemia diagnosis.
Data show that BST2 directly binds to purified ILT7, initiates signaling via the ILT7-FcepsilonRIgamma complex, and regulates TLR7/9 responses in plasmacytoid dendritic cells.
Title: Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.
Observational study of gene-disease association. (HuGE Navigator)
Title: Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
key regulator of human pDC function and interferon type I production.
Title: SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production.
ILT7 protein associates with the signal adapter protein Fc epsilonRI gamma to form a receptor complex in dendritic cells.
Title: Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production.
the expression of immunoglobulin-like transcript 7, in plasmacytoid dendritic cells
Title: Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpu	vpu	Vpu-mediated suppresion of IFN-1 production requires engagement and activation of the LILRA4 (ILT7) plasmacytoid dendritic cell receptor by BST2	PubMed

Go to the HIV-1, Human Interaction Database

General gene information

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Markers

REN92482 (e-PCR)
- UniSTS:417280

REN92483 (e-PCR)
- UniSTS:417281

REN92484 (e-PCR)
- UniSTS:417282

REN92485 (e-PCR)
- UniSTS:417283

REN92486 (e-PCR)
- UniSTS:417284

REN92487 (e-PCR)
- UniSTS:417285

REN92488 (e-PCR)
- UniSTS:417286

REN92489 (e-PCR)
- UniSTS:417287

REN92490 (e-PCR)
- UniSTS:417288

REN92491 (e-PCR)
- UniSTS:417289

REN92492 (e-PCR)
- UniSTS:417290

REN92493 (e-PCR)
- UniSTS:417291

REN92494 (e-PCR)
- UniSTS:417292

ECD02824 (e-PCR)
- UniSTS:283917

REN92495 (e-PCR)
- UniSTS:417293

REN92496 (e-PCR)
- UniSTS:417294

ECD04646 (e-PCR)
- UniSTS:285717

ECD03637 (e-PCR)
- UniSTS:284717

ECD04690 (e-PCR)
- UniSTS:285761

NoName (e-PCR)
- UniSTS:481870

stSG605983 (e-PCR)
- UniSTS:448094

ECD02654 (e-PCR)
- UniSTS:283748

NoName (e-PCR)
- UniSTS:483952

ECD05284 (e-PCR)
- UniSTS:286350

ECD01942 (e-PCR)
- UniSTS:283043

RH46148 (e-PCR)
- UniSTS:78540

REN92462 (e-PCR)
- UniSTS:417260

REN92463 (e-PCR)
- UniSTS:417261

REN92464 (e-PCR)
- UniSTS:417262

REN92465 (e-PCR)
- UniSTS:417263

REN92466 (e-PCR)
- UniSTS:417264

REN92467 (e-PCR)
- UniSTS:417265

REN92468 (e-PCR)
- UniSTS:417266

REN92469 (e-PCR)
- UniSTS:417267

REN92470 (e-PCR)
- UniSTS:417268

REN92471 (e-PCR)
- UniSTS:417269

REN92472 (e-PCR)
- UniSTS:417270

REN92473 (e-PCR)
- UniSTS:417271

REN92474 (e-PCR)
- UniSTS:417272

REN92475 (e-PCR)
- UniSTS:417273

REN92476 (e-PCR)
- UniSTS:417274

REN92477 (e-PCR)
- UniSTS:417275

REN92478 (e-PCR)
- UniSTS:417276

REN92479 (e-PCR)
- UniSTS:417277

REN93760 (e-PCR)
- UniSTS:418558

REN92481 (e-PCR)
- UniSTS:417279

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables coreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables inhibitory MHC class I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Fc-epsilon receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interferon-alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 7 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 9 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Fc-epsilon receptor I complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leukocyte immunoglobulin-like receptor subfamily A member 4

Names: CD85 antigen-like family member G; immunoglobulin-like transcript 7; leucocyte Ig-like receptor A4; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012276.5 → NP_036408.4 leukocyte immunoglobulin-like receptor subfamily A member 4 precursor

Status: REVIEWED

Source sequence(s)

AC245884, AF283989, BI834628, DA983933

Consensus CDS

CCDS12890.1

UniProtKB/Swiss-Prot

P59901, Q32MC4

UniProtKB/TrEMBL

A0A0G2JNG2

Related

ENSP00000291759.4, ENST00000291759.5

Conserved Domains (2) summary

smart00410
Location:233 → 295

IG_like; Immunoglobulin like

cl11960
Location:122 → 217

Ig; Immunoglobulin domain