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    CMIP c-Maf inducing protein [ Homo sapiens (human) ]

    Gene ID: 80790, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CMIPprovided by HGNC
    Official Full Name
    c-Maf inducing proteinprovided by HGNC
    Primary source
    HGNC:HGNC:24319
    See related
    Ensembl:ENSG00000153815 MIM:610112; AllianceGenome:HGNC:24319
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCMIP
    Summary
    This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in brain (RPKM 12.0), small intestine (RPKM 8.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CMIP in Genome Data Viewer
    Location:
    16q23.2-q23.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (81444808..81711762)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (87505643..87774006)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (81478413..81745367)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7755 Neighboring gene beta-carotene oxygenase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:81420479-81420673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81431403-81431953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81430852-81431402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11179 Neighboring gene gigaxonin Neighboring gene Sharpr-MPRA regulatory region 12949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81466113-81467024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81467025-81467934 Neighboring gene microRNA 4720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81477254-81477786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81479951-81480716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81480717-81481480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81482247-81483010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81489297-81489981 Neighboring gene Sharpr-MPRA regulatory region 2768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81491353-81492038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81497377-81497916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81503436-81503936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81527049-81527782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81530785-81531426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11189 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81546458-81547288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81549519-81550168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81553011-81553629 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:81551802-81552499 Neighboring gene peptidylprolyl isomerase A pseudogene 51 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81565885-81566386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81566387-81566886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81586378-81586984 Neighboring gene Sharpr-MPRA regulatory region 2593 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81615785-81616602 Neighboring gene microRNA 7854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81625679-81626527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81626528-81627375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81649495-81650338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81650339-81651181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81652108-81652708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11195 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81660988-81661609 Neighboring gene uncharacterized LOC105371362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81666826-81667665 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81667666-81668506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81678346-81679052 Neighboring gene Sharpr-MPRA regulatory region 7704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11196 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81686310-81687034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81687035-81687760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81695233-81696130 Neighboring gene microRNA 6504 Neighboring gene uncharacterized LOC100129617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81716567-81717362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81719349-81720088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81720089-81720826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81724705-81725344 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:81738285-81738786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81745144-81745826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81746509-81747190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:81747191-81747871 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:81750745-81750968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11199 Neighboring gene Sharpr-MPRA regulatory region 4528 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:81758203-81758451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:81770025-81770957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81772148-81772930 Neighboring gene uncharacterized LOC105369213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81779157-81779776 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:81780739-81780931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11203 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81785671-81786279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81786280-81786887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11204 Neighboring gene Sharpr-MPRA regulatory region 4151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7763 Neighboring gene Sharpr-MPRA regulatory region 14941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11211 Neighboring gene phospholipase C gamma 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11221 Neighboring gene uncharacterized LOC124903731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81864849-81865430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:81865431-81866012

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppargamma-CD36 axis.
      Title: Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.
    2. CMIP interacts with WT1 and targets it on the proteasome degradation pathway.
      Title: CMIP interacts with WT1 and targets it on the proteasome degradation pathway.
    3. CMIP is a negative regulator of T cell signaling.
      Title: CMIP is a negative regulator of T cell signaling.
    4. CMIP SNPs and their haplotypes are associated with dyslipidaemia and clinicopathologic features of IgA nephropathy.
      Title: CMIP SNPs and their haplotypes are associated with dyslipidaemia and clinicopathologic features of IgA nephropathy.
    5. CMIP promotes Herceptin resistance of HER2 positive gastric cancer cells.
      Title: CMIP promotes Herceptin resistance of HER2 positive gastric cancer cells.
    6. Expression of CMIP in podocytes is restricted to specific classes of lupus nephritis
      Title: Expression of CMIP in podocytes is restricted to specific classes of lupus nephritis.
    7. Genome-wide significant (P < 5 x 10(-8) ) interaction with MTNR1B and joint effects were detected for CMIP intronic rs17197883.
      Title: Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans.
    8. each copy of CMIP rs2925979_T allele was associated with a 29% higher risk of T2DM in females (p = 9.30 x 10(-4)), while it was not significantly associated with T2DM in males (p = 0.705).
      Title: Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.
    9. CMIP knockdown was observed to result in the downregulation of MDM2 and mitogen activated protein kinase (MAPK) expression at the mRNA level and CMIP was a direct target of miR1013p.
      Title: CMIP is oncogenic in human gastric cancer cells.
    10. CMIP is oncogenic and could be a potential target for human glioma diagnosis and therapy.
      Title: CMIP Promotes Proliferation and Metastasis in Human Glioma.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
    EBI GWAS Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
    EBI GWAS Catalog
    Genome wide association study of age at menarche in the Japanese population.
    EBI GWAS Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
    EBI GWAS Catalog
    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1694

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    C-Maf-inducing protein
    Names
    tc-Mip

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029839.1 RefSeqGene

      Range
      4639..271593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_030629.3 → NP_085132.1  C-Maf-inducing protein isoform Tc-Mip

      See identical proteins and their annotated locations for NP_085132.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in a shorter isoform (Tc-Mip) with a distinct N-terminus compared to isoform C-Mip. This isoform lacks the NH2-terminal PH domain, is specifically recruited to PBMCs in MCNS patients, and thought to play a role in T-cell signaling pathway.
      Source sequence(s)
      AY172689, BM789770
      Consensus CDS
      CCDS54045.1
      UniProtKB/TrEMBL
      B7Z942
      Related
      ENSP00000440401.2, ENST00000539778.6
      Conserved Domains (2) summary
      sd00034
      Location:570 → 593
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl28166
      Location:500 → 674
      AMN1; Antagonist of mitotic exit network protein 1

    2. NM_198390.3 → NP_938204.2  C-Maf-inducing protein isoform C-Mip

      See identical proteins and their annotated locations for NP_938204.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (C-Mip). This variant is predominantly expressed in fetal liver, kidney, and peripheral blood mononuclear cells (PBMCs), but weakly detected in PBMCs from minimal change nephrotic syndrome (MCNS) patients.
      Source sequence(s)
      AB051481, AC092139, BM789770, CV570964
      Consensus CDS
      CCDS54044.1
      UniProtKB/Swiss-Prot
      Q8IY22, Q9C0G9
      Related
      ENSP00000446100.2, ENST00000537098.8
      Conserved Domains (2) summary
      cd09293
      Location:594 → 768
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:664 → 687
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      81444808..81711762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434717.1 → XP_047290673.1  C-Maf-inducing protein isoform X1

    2. XM_011523352.2 → XP_011521654.1  C-Maf-inducing protein isoform X2

      See identical proteins and their annotated locations for XP_011521654.1

      Conserved Domains (2) summary
      sd00034
      Location:648 → 671
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl39015
      Location:647 → 755
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. XM_005256179.6 → XP_005256236.5  C-Maf-inducing protein isoform X3

    4. XM_005256181.3 → XP_005256238.1  C-Maf-inducing protein isoform X5

      See identical proteins and their annotated locations for XP_005256238.1

      UniProtKB/TrEMBL
      A0A087WU05, B7Z942
      Related
      ENSP00000478272.1, ENST00000566513.5
      Conserved Domains (2) summary
      cd09293
      Location:442 → 581
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:477 → 500
      LRR_AMN1; leucine-rich repeat [structural motif]

    5. XM_017023733.2 → XP_016879222.1  C-Maf-inducing protein isoform X5

      UniProtKB/TrEMBL
      A0A087WU05, B7Z942
      Conserved Domains (2) summary
      cd09293
      Location:442 → 581
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:477 → 500
      LRR_AMN1; leucine-rich repeat [structural motif]

    6. XM_047434719.1 → XP_047290675.1  C-Maf-inducing protein isoform X4

      Related
      ENSP00000381120.4, ENST00000398040.8

    7. XM_047434721.1 → XP_047290677.1  C-Maf-inducing protein isoform X5

      UniProtKB/TrEMBL
      A0A087WU05

    8. XM_047434720.1 → XP_047290676.1  C-Maf-inducing protein isoform X5

      UniProtKB/TrEMBL
      A0A087WU05

    9. XM_005256182.1 → XP_005256239.1  C-Maf-inducing protein isoform X5

      See identical proteins and their annotated locations for XP_005256239.1

      UniProtKB/TrEMBL
      A0A087WU05, B7Z942
      Conserved Domains (2) summary
      cd09293
      Location:442 → 581
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:477 → 500
      LRR_AMN1; leucine-rich repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      87505643..87774006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314052.1 → XP_054170027.1  C-Maf-inducing protein isoform X1

    2. XM_054314053.1 → XP_054170028.1  C-Maf-inducing protein isoform X2

    3. XM_054314054.1 → XP_054170029.1  C-Maf-inducing protein isoform X6

    4. XM_054314058.1 → XP_054170033.1  C-Maf-inducing protein isoform X5

      UniProtKB/TrEMBL
      A0A087WU05

    5. XM_054314057.1 → XP_054170032.1  C-Maf-inducing protein isoform X5

      UniProtKB/TrEMBL
      A0A087WU05

    6. XM_054314055.1 → XP_054170030.1  C-Maf-inducing protein isoform X4

    7. XM_054314056.1 → XP_054170031.1  C-Maf-inducing protein isoform X5

      UniProtKB/TrEMBL
      A0A087WU05
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IY22.3 GenPept UniProtKB/Swiss-Prot:Q8IY22

    Gene LinkOut

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