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    BAZ2A bromodomain adjacent to zinc finger domain 2A [ Homo sapiens (human) ]

    Gene ID: 11176, updated on 14-Nov-2024

    Summary

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    Official Symbol
    BAZ2Aprovided by HGNC
    Official Full Name
    bromodomain adjacent to zinc finger domain 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:962
    See related
    Ensembl:ENSG00000076108 MIM:605682; AllianceGenome:HGNC:962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIP5; WALp3
    Summary
    Enables histone binding activity. Contributes to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation-dependent heterochromatin formation; negative regulation of transcription by RNA polymerase I; and rDNA heterochromatin formation. Predicted to act upstream of or within heterochromatin formation. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 26.6), placenta (RPKM 20.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BAZ2A in Genome Data Viewer
    Location:
    12q13.3
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56595596..56638318, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56563591..56604975, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56989380..57030143, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 105C Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56916039-56916782 Neighboring gene RNA binding motif single stranded interacting protein 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56959127-56959665 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56959666-56960203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6503 Neighboring gene RNA, U6 small nuclear 343, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:57020987-57021488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:57029126-57029638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6509 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:57030665-57031176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:57038866-57039576 Neighboring gene ATP synthase F1 subunit beta Neighboring gene small nucleolar RNA, C/D box 59B Neighboring gene small nucleolar RNA, C/D box 59A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer. Liu Y, et al. Sci Rep, 2024 Mar 4. PMID 38433277, Free PMC Article
    2. A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes. Anosova I, et al. Nucleic Acids Res, 2015 May 26. PMID 25916849, Free PMC Article
    3. Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. Tallant C, et al. Structure, 2015 Jan 6. PMID 25533489, Free PMC Article
    4. BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence. Gu L, et al. Nat Genet, 2015 Jan. PMID 25485837
    5. lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs. Savić N, et al. Cell Stem Cell, 2014 Dec 4. PMID 25479748

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer.
      Title: Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer.
    2. Nasopharyngeal carcinoma derived exosomes regulate the proliferation and migration of nasopharyngeal carcinoma cells by mediating the miR-99a-5p BAZ2A axis.
      Title: Nasopharyngeal carcinoma derived exosomes regulate the proliferation and migration of nasopharyngeal carcinoma cells by mediating the miR-99a-5p BAZ2A axis.
    3. BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer.
      Title: BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer.
    4. BAZ2A-mediated repression via H3K14ac-marked enhancers promotes prostate cancer stem cells.
      Title: BAZ2A-mediated repression via H3K14ac-marked enhancers promotes prostate cancer stem cells.
    5. Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status.
      Title: Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status.
    6. the results of the present study demonstrated that TIP5 regulates beta-catenin/TCF7L2 signaling via TIP5 during HCC progression and suggests that TIP5 may be a promising therapeutic target for the treatment of HCC.
      Title: The transcription factor 7 like 2‑binding protein TIP5 activates β‑catenin/transcription factor signaling in hepatocellular carcinoma.
    7. Data suggest that binding of helical tail of histone 3 (H3) with PHD ('plant homeodomain') fingers of BAZ2A or BAZ2B (bromodomain adjacent to zinc finger domain 2A or 2B) requires molecular recognition of secondary structure motifs within H3 tail and could represent an additional layer of regulation in epigenetic processes.
      Title: Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.
    8. Data show that SUMOylated BANP, E5R, and Nac1 (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1-interacting protein 5 (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase
      Title: BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.
    9. Crystal structures of PHD zinc finger and bromodomains from human TIP5 and BAZ2B in free form and bound to H3 and/or H4 histones.
      Title: Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.
    10. The study showed that the NMR structure of the TAM domain of TIP5 resembles the fold of the MBD domain, found in methyl-CpG binding proteins.
      Title: A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    New gene functions in megakaryopoiesis and platelet formation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13768, FLJ13780, FLJ45876, KIAA0314, DKFZp781B109

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to RNA polymerase I core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lysine-acetylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent constitutive heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in RNA polymerase I preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rDNA heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rDNA heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NoRC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin silencing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rDNA heterochromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain adjacent to zinc finger domain protein 2A
    Names
    TTF-I interacting peptide 5
    TTF-I-interacting protein 5
    transcription termination factor I-interacting protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300905.2 → NP_001287834.1  bromodomain adjacent to zinc finger domain protein 2A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter, differs in the 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC090681, AK023842, DB215236
      Consensus CDS
      CCDS73483.1
      UniProtKB/TrEMBL
      F8VU39
      Related
      ENSP00000447941.1, ENST00000549884.6
      Conserved Domains (5) summary
      cd05503
      Location:1796 → 1892
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:846 → 911
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:549 → 621
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1676 → 1722
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15614
      Location:1437 → 1475
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

    2. NM_001351156.2 → NP_001338085.1  bromodomain adjacent to zinc finger domain protein 2A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes isoform 3.
      Source sequence(s)
      AC090681
      Related
      ENSP00000368754.3, ENST00000379441.7
      Conserved Domains (7) summary
      cd05503
      Location:1766 → 1862
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:816 → 881
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:519 → 591
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1646 → 1692
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15613
      Location:1407 → 1441
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl26170
      Location:360 → 492
      DUF4115; Domain of unknown function (DUF4115)
      cl27975
      Location:1295 → 1398
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

    3. NM_013449.4 → NP_038477.2  bromodomain adjacent to zinc finger domain protein 2A isoform 1

      See identical proteins and their annotated locations for NP_038477.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC090681, AK023842, CD686304, CR749379
      Consensus CDS
      CCDS44924.1
      UniProtKB/Swiss-Prot
      B3KN66, O00536, O15030, Q68DI8, Q96H26, Q9UIF9
      Related
      ENSP00000446880.1, ENST00000551812.5
      Conserved Domains (5) summary
      cd05503
      Location:1798 → 1894
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:848 → 913
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:551 → 623
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1678 → 1724
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15614
      Location:1439 → 1477
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      56595596..56638318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428142.1 → XP_047284098.1  bromodomain adjacent to zinc finger domain protein 2A isoform X4

    2. XM_047428148.1 → XP_047284104.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

    3. XM_047428155.1 → XP_047284111.1  bromodomain adjacent to zinc finger domain protein 2A isoform X12

    4. XM_047428151.1 → XP_047284107.1  bromodomain adjacent to zinc finger domain protein 2A isoform X9

    5. XM_047428145.1 → XP_047284101.1  bromodomain adjacent to zinc finger domain protein 2A isoform X7

    6. XM_047428166.1 → XP_047284122.1  bromodomain adjacent to zinc finger domain protein 2A isoform X18

    7. XM_047428144.1 → XP_047284100.1  bromodomain adjacent to zinc finger domain protein 2A isoform X6

    8. XM_047428141.1 → XP_047284097.1  bromodomain adjacent to zinc finger domain protein 2A isoform X3

    9. XM_047428139.1 → XP_047284095.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    10. XM_047428147.1 → XP_047284103.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

    11. XM_047428159.1 → XP_047284115.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    12. XM_047428157.1 → XP_047284113.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    13. XM_047428164.1 → XP_047284120.1  bromodomain adjacent to zinc finger domain protein 2A isoform X16

    14. XM_047428163.1 → XP_047284119.1  bromodomain adjacent to zinc finger domain protein 2A isoform X15

    15. XM_047428153.1 → XP_047284109.1  bromodomain adjacent to zinc finger domain protein 2A isoform X11

    16. XM_047428158.1 → XP_047284114.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    17. XM_047428149.1 → XP_047284105.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

    18. XM_047428169.1 → XP_047284125.1  bromodomain adjacent to zinc finger domain protein 2A isoform X20

    19. XM_047428168.1 → XP_047284124.1  bromodomain adjacent to zinc finger domain protein 2A isoform X10

    20. XM_047428167.1 → XP_047284123.1  bromodomain adjacent to zinc finger domain protein 2A isoform X19

    21. XM_047428162.1 → XP_047284118.1  bromodomain adjacent to zinc finger domain protein 2A isoform X14

    22. XM_047428161.1 → XP_047284117.1  bromodomain adjacent to zinc finger domain protein 2A isoform X5

      UniProtKB/TrEMBL
      F8VU39

    23. XM_011537806.3 → XP_011536108.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      See identical proteins and their annotated locations for XP_011536108.1

      Conserved Domains (5) summary
      cd05503
      Location:1803 → 1899
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:846 → 911
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:549 → 621
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1683 → 1729
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15614
      Location:1437 → 1475
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

    24. XM_017018741.2 → XP_016874230.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      Conserved Domains (5) summary
      cd05503
      Location:1803 → 1899
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:846 → 911
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:549 → 621
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1683 → 1729
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15614
      Location:1437 → 1475
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

    25. XM_047428150.1 → XP_047284106.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

    26. XM_047428165.1 → XP_047284121.1  bromodomain adjacent to zinc finger domain protein 2A isoform X17

    27. XM_047428156.1 → XP_047284112.1  bromodomain adjacent to zinc finger domain protein 2A isoform X13

    28. XM_047428154.1 → XP_047284110.1  bromodomain adjacent to zinc finger domain protein 2A isoform X11

    29. XM_047428146.1 → XP_047284102.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

    30. XM_011537805.3 → XP_011536107.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

      See identical proteins and their annotated locations for XP_011536107.1

      Conserved Domains (5) summary
      cd05503
      Location:1803 → 1899
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:846 → 911
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:549 → 621
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1683 → 1729
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15614
      Location:1437 → 1475
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

    31. XM_047428160.1 → XP_047284116.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    32. XM_047428143.1 → XP_047284099.1  bromodomain adjacent to zinc finger domain protein 2A isoform X5

      UniProtKB/TrEMBL
      F8VU39

    33. XM_047428140.1 → XP_047284096.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    34. XM_047428152.1 → XP_047284108.1  bromodomain adjacent to zinc finger domain protein 2A isoform X10

    35. XM_011537809.3 → XP_011536111.1  bromodomain adjacent to zinc finger domain protein 2A isoform X21

      Conserved Domains (5) summary
      cd05503
      Location:1255 → 1351
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:298 → 363
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:10 → 73
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15629
      Location:1135 → 1181
      PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
      pfam15614
      Location:889 → 927
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

    36. XM_047428170.1 → XP_047284126.1  bromodomain adjacent to zinc finger domain protein 2A isoform X22

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      56563591..56604975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370868.1 → XP_054226843.1  bromodomain adjacent to zinc finger domain protein 2A isoform X4

    2. XM_054370870.1 → XP_054226845.1  bromodomain adjacent to zinc finger domain protein 2A isoform X6

    3. XM_054370879.1 → XP_054226854.1  bromodomain adjacent to zinc finger domain protein 2A isoform X27

    4. XM_054370875.1 → XP_054226850.1  bromodomain adjacent to zinc finger domain protein 2A isoform X26

      UniProtKB/TrEMBL
      J3KPG5

    5. XM_054370871.1 → XP_054226846.1  bromodomain adjacent to zinc finger domain protein 2A isoform X25

    6. XM_054370894.1 → XP_054226869.1  bromodomain adjacent to zinc finger domain protein 2A isoform X28

    7. XM_054370867.1 → XP_054226842.1  bromodomain adjacent to zinc finger domain protein 2A isoform X24

    8. XM_054370865.1 → XP_054226840.1  bromodomain adjacent to zinc finger domain protein 2A isoform X23

    9. XM_054370886.1 → XP_054226861.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    10. XM_054370883.1 → XP_054226858.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    11. XM_054370892.1 → XP_054226867.1  bromodomain adjacent to zinc finger domain protein 2A isoform X16

    12. XM_054370891.1 → XP_054226866.1  bromodomain adjacent to zinc finger domain protein 2A isoform X15

    13. XM_054370880.1 → XP_054226855.1  bromodomain adjacent to zinc finger domain protein 2A isoform X13

    14. XM_054370877.1 → XP_054226852.1  bromodomain adjacent to zinc finger domain protein 2A isoform X11

    15. XM_054370872.1 → XP_054226847.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

    16. XM_054370884.1 → XP_054226859.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    17. XM_054370874.1 → XP_054226849.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

    18. XM_054370889.1 → XP_054226864.1  bromodomain adjacent to zinc finger domain protein 2A isoform X5

      UniProtKB/TrEMBL
      F8VU39

    19. XM_054370890.1 → XP_054226865.1  bromodomain adjacent to zinc finger domain protein 2A isoform X14

    20. XM_054370882.1 → XP_054226857.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    21. XM_054370896.1 → XP_054226871.1  bromodomain adjacent to zinc finger domain protein 2A isoform X10

    22. XM_054370897.1 → XP_054226872.1  bromodomain adjacent to zinc finger domain protein 2A isoform X20

    23. XM_054370895.1 → XP_054226870.1  bromodomain adjacent to zinc finger domain protein 2A isoform X19

    24. XM_054370885.1 → XP_054226860.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    25. XM_054370893.1 → XP_054226868.1  bromodomain adjacent to zinc finger domain protein 2A isoform X17

    26. XM_054370881.1 → XP_054226856.1  bromodomain adjacent to zinc finger domain protein 2A isoform X13

    27. XM_054370878.1 → XP_054226853.1  bromodomain adjacent to zinc finger domain protein 2A isoform X11

    28. XM_054370873.1 → XP_054226848.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

    29. XM_054370887.1 → XP_054226862.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    30. XM_054370888.1 → XP_054226863.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    31. XM_054370869.1 → XP_054226844.1  bromodomain adjacent to zinc finger domain protein 2A isoform X5

      UniProtKB/TrEMBL
      F8VU39

    32. XM_054370866.1 → XP_054226841.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    33. XM_054370876.1 → XP_054226851.1  bromodomain adjacent to zinc finger domain protein 2A isoform X10

    34. XM_054370898.1 → XP_054226873.1  bromodomain adjacent to zinc finger domain protein 2A isoform X21

    35. XM_054370899.1 → XP_054226874.1  bromodomain adjacent to zinc finger domain protein 2A isoform X22

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UIF9.4 GenPept UniProtKB/Swiss-Prot:Q9UIF9

    Gene LinkOut

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