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    Pias1 protein inhibitor of activated STAT 1 [ Mus musculus (house mouse) ]

    Gene ID: 56469, updated on 2-Nov-2024

    Summary

    Official Symbol
    Pias1provided by MGI
    Official Full Name
    protein inhibitor of activated STAT 1provided by MGI
    Primary source
    MGI:MGI:1913125
    See related
    Ensembl:ENSMUSG00000032405 AllianceGenome:MGI:1913125
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GBP; Ddxbp1; 2900068C24Rik
    Summary
    Enables several functions, including SUMO ligase activity; transcription cis-regulatory region binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein sumoylation. Located in nuclear periphery. Is active in glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Colocalizes with PML body. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; sensory organ; and trunk mesenchyme. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.8), lung adult (RPKM 10.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pias1 in Genome Data Viewer
    Location:
    9 B; 9 33.91 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62785648..62888161, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62878366..62980879, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ribsomal protein S2 pseudogene Neighboring gene ceroid-lipofuscinosis, neuronal 6 Neighboring gene calmodulin-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E10555 Neighboring gene STARR-positive B cell enhancer ABC_E6752 Neighboring gene STARR-positive B cell enhancer ABC_E9029 Neighboring gene STARR-positive B cell enhancer ABC_E9765 Neighboring gene STARR-positive B cell enhancer ABC_E9766 Neighboring gene predicted gene, 35574 Neighboring gene predicted gene, 24526 Neighboring gene predicted gene, 39354

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SUMO ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables SUMO transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-DNA complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-DNA complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 SUMO-protein ligase PIAS1
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
    DEAD/H box-binding protein 1
    RING-type E3 ubiquitin transferase PIAS1
    protein inhibitor of activated STAT protein 1
    NP_062637.2
    XP_006511365.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019663.3NP_062637.2  E3 SUMO-protein ligase PIAS1

      See identical proteins and their annotated locations for NP_062637.2

      Status: PROVISIONAL

      Source sequence(s)
      AK075708
      Consensus CDS
      CCDS40665.1
      UniProtKB/Swiss-Prot
      O88907, Q8C6H5
      UniProtKB/TrEMBL
      Q2M4G9, Q3U556
      Related
      ENSMUSP00000096248.5, ENSMUST00000098651.6
      Conserved Domains (4) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      COG5222
      Location:313428
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16790
      Location:332379
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:137280
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      62785648..62888161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511302.4XP_006511365.1  E3 SUMO-protein ligase PIAS1 isoform X1

      UniProtKB/TrEMBL
      Q3U556
      Conserved Domains (4) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      COG5222
      Location:304419
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16790
      Location:323370
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:128271
      PINIT; PINIT domain