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    MYO10 myosin X [ Homo sapiens (human) ]

    Gene ID: 4651, updated on 3-Nov-2024

    Summary

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    Official Symbol
    MYO10provided by HGNC
    Official Full Name
    myosin Xprovided by HGNC
    Primary source
    HGNC:HGNC:7593
    See related
    Ensembl:ENSG00000145555 MIM:601481; AllianceGenome:HGNC:7593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MyoX
    Summary
    This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in brain (RPKM 12.7), thyroid (RPKM 12.2) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYO10 in Genome Data Viewer
    Location:
    5p15.1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (16661907..16936288, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (16601148..16875413, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (16662016..16936397, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22421 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16467094-16467316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22423 Neighboring gene zinc finger protein 622 Neighboring gene reticulophagy regulator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16535515-16536016 Neighboring gene Sharpr-MPRA regulatory region 7449 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:16575232-16575796 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16606665-16606881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15947 Neighboring gene RETREG1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16711171-16711672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16718131-16718712 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:16721745-16722434 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16741941-16742846 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:16741036-16741940 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:16754668-16755308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16755309-16755949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794335-16794862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794863-16795390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16805998-16806498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16806499-16806999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:16809483-16809982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16829693-16830613 Neighboring gene RNA, 5S ribosomal pseudogene 179 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83741 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:16897552-16898412 Neighboring gene ribosomal protein S26 pseudogene 28 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16951303-16951587 Neighboring gene RNA, U6 small nuclear 660, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:16994519-16995071 Neighboring gene NANOG hESC enhancer GRCh37_chr5:17066008-17066589 Neighboring gene uncharacterized LOC124900947 Neighboring gene Sharpr-MPRA regulatory region 7707

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds. Kwon M, et al. Dev Cell, 2015 Aug 10. PMID 26235048, Free PMC Article
    2. Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer. He JH, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 32618228, Free PMC Article
    3. Myosin-X and talin modulate integrin activity at filopodia tips. Miihkinen M, et al. Cell Rep, 2021 Sep 14. PMID 34525374, Free PMC Article
    4. CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling. Chen J, et al. Mol Cancer, 2019 Oct 29. PMID 31665067, Free PMC Article
    5. Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread. Bishai EA, et al. Cell Microbiol, 2013 Mar. PMID 23083060, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYO10 regulates genome stability and cancer inflammation through mediating mitosis.
      Title: MYO10 regulates genome stability and cancer inflammation through mediating mitosis.
    2. MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling.
      Title: MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling.
    3. MYO10-filopodia support basement membranes at pre-invasive tumor boundaries.
      Title: MYO10-filopodia support basement membranes at pre-invasive tumor boundaries.
    4. MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesisdagger.
      Title: MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesis†.
    5. Myosin-X and talin modulate integrin activity at filopodia tips.
      Title: Myosin-X and talin modulate integrin activity at filopodia tips.
    6. Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer.
      Title: Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer.
    7. LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis.
      Title: LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis.
    8. We demonstrated that circMYO10 is upregulated in OS tissues and cell lines. CircMYO10 activates Wnt/beta-catenin signaling by regulating miR-370-3p/RUVBL1 axis to promote H4K16Ac at the promoter region of beta-catenin/LEF1 target genes.
      Title: CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling.
    9. MYO10 represents a new clinical biomarker for this aggressive disease and due to its role in cellular motility and invasion
      Title: Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.
    10. miR-129 inhibited neuroblastoma growth and potentiated chemosensitivity by targeting MYO10
      Title: miR-129 inhibits tumor growth and potentiates chemosensitivity of neuroblastoma by targeting MYO10.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10639, FLJ21066, FLJ22268, FLJ43256, KIAA0799, MGC131988

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables plus-end directed microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end directed microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton-dependent intracellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in filopodium tip ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-X
    Names
    unconventional myosin-10
    unconventionnal myosin-X

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012334.3 → NP_036466.2  unconventional myosin-X

      Status: REVIEWED

      Source sequence(s)
      AC010607, AC024588, AF234532, AI086647, BC014956, BC150285, CA488271, DA504301
      Consensus CDS
      CCDS54834.1
      UniProtKB/Swiss-Prot
      A7E2D1, O94893, Q8IVX5, Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6
      UniProtKB/TrEMBL
      A0A0A0MQX1
      Related
      ENSP00000421280.1, ENST00000513610.6
      Conserved Domains (12) summary
      smart00139
      Location:1549 → 1695
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58 → 739
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1704 → 1958
      B41; Band 4.1 homologues
      cd13202
      Location:1954 → 2042
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:1215 → 1316
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:1381 → 1506
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77 → 727
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:1215 → 1308
      PH; PH domain
      pfam00373
      Location:1796 → 1958
      FERM_M; FERM central domain
      pfam16735
      Location:883 → 933
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1705 → 1753
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:1181 → 1223
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      16661907..16936288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714475.4 → XP_006714538.1  unconventional myosin-X isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQX1
      Conserved Domains (12) summary
      smart00139
      Location:1526 → 1672
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58 → 716
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1681 → 1935
      B41; Band 4.1 homologues
      cd13202
      Location:1931 → 2019
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:1192 → 1293
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:1358 → 1483
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77 → 704
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:1192 → 1285
      PH; PH domain
      pfam00373
      Location:1773 → 1935
      FERM_M; FERM central domain
      pfam16735
      Location:860 → 910
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1682 → 1730
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:1158 → 1200
      PH-like; Pleckstrin homology-like domain

    2. XM_005248307.3 → XP_005248364.1  unconventional myosin-X isoform X3

      UniProtKB/TrEMBL
      B7ZA23
      Related
      ENSP00000421170.1, ENST00000505695.5
      Conserved Domains (11) summary
      smart00139
      Location:906 → 1052
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1061 → 1315
      B41; Band 4.1 homologues
      cd13202
      Location:1311 → 1399
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:572 → 673
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:738 → 863
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:1 → 84
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:572 → 665
      PH; PH domain
      pfam00373
      Location:1153 → 1315
      FERM_M; FERM central domain
      pfam16735
      Location:240 → 290
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1062 → 1110
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:538 → 580
      PH-like; Pleckstrin homology-like domain

    3. XM_011514046.3 → XP_011512348.1  unconventional myosin-X isoform X3

      UniProtKB/TrEMBL
      B7ZA23
      Related
      ENSP00000425051.1, ENST00000515803.5
      Conserved Domains (11) summary
      smart00139
      Location:906 → 1052
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1061 → 1315
      B41; Band 4.1 homologues
      cd13202
      Location:1311 → 1399
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:572 → 673
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:738 → 863
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:1 → 84
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:572 → 665
      PH; PH domain
      pfam00373
      Location:1153 → 1315
      FERM_M; FERM central domain
      pfam16735
      Location:240 → 290
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1062 → 1110
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:538 → 580
      PH-like; Pleckstrin homology-like domain

    4. XM_005248306.5 → XP_005248363.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      B7ZA23
      Conserved Domains (11) summary
      smart00139
      Location:907 → 1053
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1062 → 1316
      B41; Band 4.1 homologues
      cd13202
      Location:1312 → 1400
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:573 → 674
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:739 → 864
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:2 → 85
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:573 → 666
      PH; PH domain
      pfam00373
      Location:1154 → 1316
      FERM_M; FERM central domain
      pfam16735
      Location:241 → 291
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1063 → 1111
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:539 → 581
      PH-like; Pleckstrin homology-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      16601148..16875413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352663.1 → XP_054208638.1  unconventional myosin-X isoform X1

    2. XM_054352666.1 → XP_054208641.1  unconventional myosin-X isoform X3

      UniProtKB/TrEMBL
      B7Z3D4

    3. XM_054352665.1 → XP_054208640.1  unconventional myosin-X isoform X3

      UniProtKB/TrEMBL
      B7Z3D4

    4. XM_054352664.1 → XP_054208639.1  unconventional myosin-X isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HD67.3 GenPept UniProtKB/Swiss-Prot:Q9HD67

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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