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    PICK1 protein interacting with PRKCA 1 [ Homo sapiens (human) ]

    Gene ID: 9463, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PICK1provided by HGNC
    Official Full Name
    protein interacting with PRKCA 1provided by HGNC
    Primary source
    HGNC:HGNC:9394
    See related
    Ensembl:ENSG00000100151 MIM:605926; AllianceGenome:HGNC:9394
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PICK; PRKCABP
    Summary
    The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 10.0), testis (RPKM 8.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PICK1 in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38057255..38075701)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38518878..38537327)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38453262..38471708)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase II, I and III subunit F Neighboring gene MPRA-validated peak4487 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38378831-38379668 Neighboring gene VISTA enhancer hs564 Neighboring gene SRY-box transcription factor 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38392633-38393194 Neighboring gene VISTA enhancer hs486 Neighboring gene microRNA 4534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38424434-38424934 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:38427029-38428228 Neighboring gene VISTA enhancer hs491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38438297-38438796 Neighboring gene VISTA enhancer hs492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38446442-38446942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38446943-38447443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38452863-38453488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38453489-38454112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38470967-38471468 Neighboring gene uncharacterized LOC105373027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38476553-38477334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38479675-38480456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38482017-38482796 Neighboring gene solute carrier family 16 member 8 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38494339-38494893

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Functional roles of protein interactions with AMPA and kainate receptors. Collingridge GL, et al. Neurosci Res, 2003 Sep. PMID 12941441
    2. Protein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cells. Cockbill LM, et al. Mol Biol Cell, 2015 Dec 15. PMID 26466675, Free PMC Article
    3. PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner. Madasu Y, et al. Mol Biol Cell, 2015 Apr 1. PMID 25657323, Free PMC Article
    4. PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia. Chen YT, et al. Sci Rep, 2017 May 15. PMID 28507309, Free PMC Article
    5. Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands. Erlendsson S, et al. J Biol Chem, 2014 Sep 5. PMID 25023278, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
      Title: Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
    2. Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.
      Title: Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.
    3. The Scaffold Protein PICK1 as a Target in Chronic Pain.
      Title: The Scaffold Protein PICK1 as a Target in Chronic Pain.
    4. Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.
      Title: Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.
    5. Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.
      Title: Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.
    6. PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
      Title: PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
    7. Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.
      Title: Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.
    8. PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
      Title: PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
    9. A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
      Title: A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
    10. Arf1, AP1, and PICK1 are key coordinators of actin polymerization.
      Title: The Host GTPase Arf1 and Its Effectors AP1 and PICK1 Stimulate Actin Polymerization and Exocytosis To Promote Entry of Listeria monocytogenes.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC15204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Arp2/3 complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables G protein-coupled receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables membrane curvature sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to decreased oxygen levels ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic spine maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendritic spine maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic spine organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glial cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term synaptic depression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoamine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuronal ion channel clustering TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PRKCA-binding protein
    Names
    protein interacting with C kinase 1
    protein kinase C-alpha-binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039583.1 → NP_001034672.1  PRKCA-binding protein

      See identical proteins and their annotated locations for NP_001034672.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK092818, BC017561, CN482899
      Consensus CDS
      CCDS13965.1
      UniProtKB/Swiss-Prot
      B3KS52, O95906, Q9NRD5
      UniProtKB/TrEMBL
      B3KM22
      Related
      ENSP00000385205.3, ENST00000404072.7
      Conserved Domains (2) summary
      cd07659
      Location:146 → 360
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:19 → 99
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

    2. NM_001039584.1 → NP_001034673.1  PRKCA-binding protein

      See identical proteins and their annotated locations for NP_001034673.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK092818, BC017561
      Consensus CDS
      CCDS13965.1
      UniProtKB/Swiss-Prot
      B3KS52, O95906, Q9NRD5
      UniProtKB/TrEMBL
      B3KM22
      Related
      ENST00000484021.5
      Conserved Domains (2) summary
      cd07659
      Location:146 → 360
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:19 → 99
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

    3. NM_012407.4 → NP_036539.1  PRKCA-binding protein

      See identical proteins and their annotated locations for NP_036539.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK092818, BC017561
      Consensus CDS
      CCDS13965.1
      UniProtKB/Swiss-Prot
      B3KS52, O95906, Q9NRD5
      UniProtKB/TrEMBL
      B3KM22
      Related
      ENSP00000349465.3, ENST00000356976.8
      Conserved Domains (2) summary
      cd07659
      Location:146 → 360
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:19 → 99
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      38057255..38075701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441609.1 → XP_047297565.1  PRKCA-binding protein isoform X1

    2. XM_047441610.1 → XP_047297566.1  PRKCA-binding protein isoform X1

    3. XM_011530517.4 → XP_011528819.1  PRKCA-binding protein isoform X1

      UniProtKB/TrEMBL
      B3KM22
      Conserved Domains (2) summary
      cd07659
      Location:147 → 342
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:19 → 99
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

    4. XM_047441611.1 → XP_047297567.1  PRKCA-binding protein isoform X2

    5. XM_047441613.1 → XP_047297569.1  PRKCA-binding protein isoform X4

    6. XM_047441612.1 → XP_047297568.1  PRKCA-binding protein isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38518878..38537327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326142.1 → XP_054182117.1  PRKCA-binding protein isoform X1

    2. XM_054326143.1 → XP_054182118.1  PRKCA-binding protein isoform X1

    3. XM_054326141.1 → XP_054182116.1  PRKCA-binding protein isoform X1

    4. XM_054326144.1 → XP_054182119.1  PRKCA-binding protein isoform X2

    5. XM_054326146.1 → XP_054182121.1  PRKCA-binding protein isoform X4

    6. XM_054326145.1 → XP_054182120.1  PRKCA-binding protein isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NRD5.2 GenPept UniProtKB/Swiss-Prot:Q9NRD5

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