GJA1 gap junction protein alpha 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: GJA1provided by VGNC
Official Full Name: gap junction protein alpha 1provided by VGNC
Primary source: VGNC:VGNC:103098
See related: Ensembl:ENSSSCG00000004241
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: CX43
Expression: Biased expression in heart (RPKM 217.1), ovary (RPKM 70.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	1	NC_010443.5 (40988818..41002129, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	1	NC_010443.4 (45543880..45557193, complement)

Chromosome 1 - NC_010443.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-155-5p improves oocyte maturation in porcine cumulus cells through connexin 43-mediated regulation of MPF activity.
Title: miR-155-5p improves oocyte maturation in porcine cumulus cells through connexin 43-mediated regulation of MPF activity.
Connexin 43 Knockdown Induces Mitochondrial Dysfunction and Affects Early Developmental Competence in Porcine Embryos.
Title: Connexin 43 Knockdown Induces Mitochondrial Dysfunction and Affects Early Developmental Competence in Porcine Embryos.
Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.
Title: Localization and quantitative analysis of Cx43 in porcine oocytes during in vitro maturation.
The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.
Title: Influence of the antiandrogen flutamide on connexin 43 (Cx43) gene and protein expression in the porcine placenta and uterus during pregnancy.
we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.
Title: Androgen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostate.
The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.
Title: Real-time proliferation of porcine cumulus cells is related to the protein levels and cellular distribution of Cdk4 and Cx43.
Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.
Title: The dynamics of connexin expression, degradation and localisation are regulated by gonadotropins during the early stages of in vitro maturation of swine oocytes.
Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.
Title: Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction.
These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.
Title: Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment.
Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.
Title: No-reflow disrupts the expression and distribution of connexin 43 in a swine model.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

PMC151788P1 (e-PCR)
- UniSTS:271174

GJA1 (e-PCR)
- UniSTS:278477

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of connexin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: gap junction alpha-1 protein

Names: connexin 43; gap junction protein, alpha 1, 43kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244212.1 → NP_001231141.1 gap junction alpha-1 protein

Status: VALIDATED

Source sequence(s)

AJ293888, BF703764, CF787394, DN129019, DN129630, EV960972, EW180362, EW652303

UniProtKB/Swiss-Prot

Q29101, Q6TYA4

UniProtKB/TrEMBL

A0A287AB74, A0A4X1TJW2, F1SF43

Related

ENSSSCP00000004580.2, ENSSSCT00000004688.5

Conserved Domains (4) summary

smart00037
Location:43 → 76

CNX; Connexin homologues

smart01089
Location:165 → 231

Connexin_CCC; Gap junction channel protein cysteine-rich domain

pfam00029
Location:3 → 233

Connexin; Connexin

pfam03508
Location:293 → 312

Connexin43; Gap junction alpha-1 protein (Cx43)