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    DKK3 dickkopf WNT signaling pathway inhibitor 3 [ Sus scrofa (pig) ]

    Gene ID: 664653, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DKK3provided by VGNC
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 3provided by VGNC
    Primary source
    VGNC:VGNC:87323
    See related
    Ensembl:ENSSSCG00000013401
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in ovary (RPKM 53.6), heart (RPKM 27.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See DKK3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (47385244..47444664)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (50699247..50758562)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102160616 Neighboring gene uncharacterized LOC110259726 Neighboring gene ubiquitin specific peptidase 47 Neighboring gene G1/S-specific cyclin-E1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables co-receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dickkopf-related protein 3
    Names
    dickkopf 3 homolog
    dickkopf homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039749.1 → NP_001034838.1  dickkopf-related protein 3 precursor

      See identical proteins and their annotated locations for NP_001034838.1

      Status: PROVISIONAL

      Source sequence(s)
      AB232525
      UniProtKB/TrEMBL
      A0A4X1TS89, A0A5G2QGW8, A0A8D1RUV7, Q2HWR5
      Related
      ENSSSCP00000061257.1, ENSSSCT00000072979.1
      Conserved Domains (2) summary
      pfam06607
      Location:208 → 273
      Prokineticin; Prokineticin
      pfam04706
      Location:147 → 196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      47385244..47444664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021082083.1 → XP_020937742.1  dickkopf-related protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A4X1TMF2, F6Q5E9
      Related
      ENSSSCP00000014246.2, ENSSSCT00000014641.4
      Conserved Domains (2) summary
      pfam06607
      Location:225 → 290
      Prokineticin
      pfam04706
      Location:164 → 213
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    2. XM_005661123.3 → XP_005661180.2  dickkopf-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A4X1TMF2
      Related
      ENSSSCP00000033075.2, ENSSSCT00000061517.2
      Conserved Domains (2) summary
      pfam06607
      Location:221 → 286
      Prokineticin
      pfam04706
      Location:160 → 209
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    Nucleotide Protein
    Heading Accession and Version

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