NPPB natriuretic peptide B [Sus scrofa (pig)] - Gene

Summary

Official Symbol: NPPBprovided by VGNC
Official Full Name: natriuretic peptide Bprovided by VGNC
Primary source: VGNC:VGNC:110690
See related: Ensembl:ENSSSCG00000003431
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: BNP; BNP1; Iso-ANP
Expression: Restricted expression toward heart (RPKM 59.6) See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (71930374..71931843, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (65840061..65841530, complement)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of insulin on natriuretic peptide gene expression in porcine heart.
Title: Effect of insulin on natriuretic peptide gene expression in porcine heart.
CNP and BNP serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals
Title: Brain natriuretic peptide and C-type natriuretic peptide maintain porcine oocyte meiotic arrest.
ANP and BNP gene expression differs considerably between cardiac chambers in the first 72 hours of life in healthy piglets, resembling the transition from fetal to neonate circulation. The cardiac gene expression does not explain plasma concentrations.
Title: Cardiac natriuretic Peptide gene expression and plasma concentrations during the first 72 hours of life in piglets.
Up-regulation of BNP and a reduction in a ratio of sarcoplasmic reticulum calcium ATPase 2a in failing myocardium are observed in a porcine model of tachycardia.
Title: Development of porcine model of chronic tachycardia-induced cardiomyopathy.
serum levels predict mortality in chest pain patients in Argentina
Title: B-type natriuretic peptide and high sensitive C-reactive protein predict 2-year all cause mortality in chest pain patients: a prospective observational study from Salta, Argentina.
Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions.
Title: Signaling molecules for early detection of adverse interactions during mechanical ventilation in animal models.
identification and characterization of a novel alternatively spliced variant of porcine and human NPPB resulting from exon 2 skipping
Title: Exon-skipping brain natriuretic peptide variant is overexpressed in failing myocardium and attenuates brain natriuretic peptide production in vitro.
Regional differences in BNP and CNP expression were observed in myocardium with sustained left ventricular dyssynchronous contraction.
Title: Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure.
Arial natriuretic factor (ANF) and N-terminal proANF may be better suited than brain natriuretic peptide as markers of cardiac preload during the development and treatment of acute heart failure.
Title: Cardiac secretion of atrial and brain natriuretic peptides in acute ischaemic heart failure in pigs: effect of angiotensin II receptor antagonism.

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General gene information

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Markers

BNP (e-PCR)
- UniSTS:253850

BNP1 (e-PCR)
- UniSTS:253089

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: natriuretic peptides B

Names: brain natriuretic factor prohormone; brain natriuretic peptide; gamma-brain natriuretic peptide; preproBNP; proBNP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213846.1 → NP_999011.1 natriuretic peptides B precursor

See identical proteins and their annotated locations for NP_999011.1

Status: PROVISIONAL

Source sequence(s)

M23596

UniProtKB/Swiss-Prot

P07634

Related

ENSSSCP00000003722.2, ENSSSCT00000003809.5

Conserved Domains (2) summary

pfam00212
Location:95 → 125

ANP; Atrial natriuretic peptide

cl23717
Location:27 → 78

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...