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    MTHFR methylenetetrahydrofolate reductase [ Sus scrofa (pig) ]

    Gene ID: 397180, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MTHFRprovided by VGNC
    Official Full Name
    methylenetetrahydrofolate reductaseprovided by VGNC
    Primary source
    VGNC:VGNC:90451
    See related
    Ensembl:ENSSSCG00000003428
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in ovary (RPKM 6.6), liver (RPKM 4.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See MTHFR in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (71863637..71882118, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (65776804..65791405, complement)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene angiotensin II receptor associated protein Neighboring gene uncharacterized LOC110261388 Neighboring gene uncharacterized protein C1orf167 Neighboring gene chloride voltage-gated channel 6 Neighboring gene natriuretic peptide A Neighboring gene natriuretic peptide B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of breed, parity, and folic Acid supplement on the expression of folate metabolism genes in endometrial and embryonic tissues from sows in early pregnancy. Vallée M, et al. Biol Reprod, 2002 Oct. PMID 12297544
    2. Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms. Tran P, et al. Mamm Genome, 2002 Sep. PMID 12370778
    3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methylenetetrahydrofolate reductase
    Names
    5,10-methylenetetrahydrofolate reductase (NADPH)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      71863637..71882118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003127574.4 → XP_003127622.1  methylenetetrahydrofolate reductase isoform X5

      See identical proteins and their annotated locations for XP_003127622.1

      UniProtKB/TrEMBL
      A0A287AUY4, A0A8D0HX37, A0A8D0HXW3, A0A8D1C5P6, F1RF82
      Related
      ENSSSCP00000047921.3, ENSSSCT00000037878.3
      Conserved Domains (1) summary
      cl00246
      Location:59 → 625
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    2. XM_005664995.3 → XP_005665052.1  methylenetetrahydrofolate reductase isoform X5

      See identical proteins and their annotated locations for XP_005665052.1

      UniProtKB/TrEMBL
      A0A287AUY4, A0A8D0HX37, A0A8D0HXW3, A0A8D1C5P6, F1RF82
      Conserved Domains (1) summary
      cl00246
      Location:59 → 625
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    3. XM_005664996.3 → XP_005665053.1  methylenetetrahydrofolate reductase isoform X5

      See identical proteins and their annotated locations for XP_005665053.1

      UniProtKB/TrEMBL
      A0A287AUY4, A0A8D0HX37, A0A8D0HXW3, A0A8D1C5P6, F1RF82
      Conserved Domains (1) summary
      cl00246
      Location:59 → 625
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    4. XM_021095344.1 → XP_020951003.1  methylenetetrahydrofolate reductase isoform X4

      UniProtKB/TrEMBL
      A0A8D0YSM6, A0A8D1YN60
      Conserved Domains (1) summary
      cl00246
      Location:59 → 663
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    5. XM_021095346.1 → XP_020951005.1  methylenetetrahydrofolate reductase isoform X4

      UniProtKB/TrEMBL
      A0A8D0YSM6, A0A8D1YN60
      Conserved Domains (1) summary
      cl00246
      Location:59 → 663
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    6. XM_021095345.1 → XP_020951004.1  methylenetetrahydrofolate reductase isoform X4

      UniProtKB/TrEMBL
      A0A8D0YSM6, A0A8D1YN60
      Conserved Domains (1) summary
      cl00246
      Location:59 → 663
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    7. XM_021095343.1 → XP_020951002.1  methylenetetrahydrofolate reductase isoform X2

      UniProtKB/TrEMBL
      A0A8D1R6C5, K9IVF1
      Conserved Domains (1) summary
      cl00246
      Location:99 → 703
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    8. XM_021095342.1 → XP_020951001.1  methylenetetrahydrofolate reductase isoform X1

      UniProtKB/TrEMBL
      A0A8D1R6C5, K9IVF1
      Conserved Domains (1) summary
      cl00246
      Location:100 → 704
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    9. XM_003127575.4 → XP_003127623.1  methylenetetrahydrofolate reductase isoform X3

      UniProtKB/TrEMBL
      A0A287B634, A0A8D1R6C5, A0A8D1YQU9, K9IVF1
      Related
      ENSSSCP00000051768.2, ENSSSCT00000042716.3
      Conserved Domains (1) summary
      cl00246
      Location:100 → 666
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    RNA

    1. XR_002344905.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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