CTNNB1 catenin beta 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CTNNB1provided by VGNC
Official Full Name: catenin beta 1provided by VGNC
Primary source: VGNC:VGNC:87065
See related: Ensembl:ENSSSCG00000011274
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in kidney (RPKM 118.5), lung (RPKM 100.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	13	NC_010455.5 (25163550..25208314)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	13	NC_010455.4 (27623189..27667260)

Chromosome 13 - NC_010455.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In this study, animal experimentation verified that the canonical Wnt/beta-catenin signaling pathway was activated under a reduced activity of p-beta-catenin (Ser33/37/Thr41) and an increased accumulation of beta-catenin in the lungs and kidneys of pigs infected with a highly virulent strain of Haemophilus parasuis.
Title: Haemophilus parasuis Infection Disrupts Adherens Junctions and Initializes EMT Dependent on Canonical Wnt/β-Catenin Signaling Pathway.
Results highlight a potential role for the beta-catenin/Wnt and Notch signalling pathways during the infection of crypt cells by L. intracellularis.
Title: Lawsonia intracellularis exploits β-catenin/Wnt and Notch signalling pathways during infection of intestinal crypt to alter cell homeostasis and promote cell proliferation.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
Title: Flutamide alters β-catenin expression and distribution, and its interactions with E-cadherin in the porcine corpus luteum of mid- and late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Title: Role of retinal pigment epithelial cell β-catenin signaling in experimental proliferative vitreoretinopathy.
Wnt3a produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
Title: Wnt3a/β-catenin increases proliferation in heart valve interstitial cells.
This study tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17beta-estradiol synthesis and the associated gene expression in large antral follicles of adult pigs.
Title: Elevated level of 17β-estradiol is associated with overexpression of FSHR, CYP19A1, and CTNNB1 genes in porcine ovarian follicles after prenatal and neonatal flutamide exposure.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
Title: β-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition.
beta-Catenin plays a critical role in mediating TGF-beta1-induced myofibroblast differentiation in aortic valve interstitial cells.
Title: β-catenin mediates mechanically regulated, transforming growth factor-β1-induced myofibroblast differentiation of aortic valve interstitial cells.
TNF-alpha inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Title: Beta-catenin protein utilized by Tumour necrosis factor-alpha in porcine preadipocytes to suppress differentiation.
Data show that Wnt3a can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
Title: Roles of Wnt/beta-catenin signaling in adipogenic differentiation potential of adipose-derived mesenchymal stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

Ctnnb1 (e-PCR), detects polymorphism
- UniSTS:508427

PMC130963P1 (e-PCR)
- UniSTS:270616

PMC130963P2 (e-PCR)
- UniSTS:270617

GDB:435507 (e-PCR)
- UniSTS:157235

PMC15782P2 (e-PCR)
- UniSTS:271431

PMC21165P1 (e-PCR)
- UniSTS:272017

EST12H1 (e-PCR)
- UniSTS:263086

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables alpha-catenin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cadherin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info	PubMed
part_of catenin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: catenin beta-1

Names: beta-catenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214367.1 → NP_999532.1 catenin beta-1

See identical proteins and their annotated locations for NP_999532.1

Status: PROVISIONAL

Source sequence(s)

AB046171

UniProtKB/TrEMBL

A0A4X1TKY9, A0A8D1UHL1, Q8WNW4

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010455.5 Reference Sscrofa11.1 Primary Assembly

Range

25163550..25208314

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_013981492.2 → XP_013836946.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A4X1TKY9, A0A8D1UHL1, Q8WNW4

Related

ENSSSCP00000031836.3, ENSSSCT00000057283.3

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
XM_005669377.3 → XP_005669434.1 catenin beta-1 isoform X1

See identical proteins and their annotated locations for XP_005669434.1

UniProtKB/TrEMBL

A0A4X1TKY9, A0A8D1UHL1, Q8WNW4

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
XM_021068564.1 → XP_020924223.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A4X1TKY9, A0A8D1UHL1, Q8WNW4

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
XM_021068565.1 → XP_020924224.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A4X1TKY9, A0A8D1UHL1, Q8WNW4

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat
XM_021068566.1 → XP_020924225.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A4X1TKY9, A0A8D1UHL1, Q8WNW4

Related

ENSSSCP00000012019.4, ENSSSCT00000012342.5

Conserved Domains (4) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

COG5064
Location:142 → 431

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]

pfam00514
Location:583 → 622

Arm; Armadillo/beta-catenin-like repeat