SMIM10L2A small integral membrane protein 10 like 2A [Homo sapiens (human)] - Gene

Summary

Official Symbol: SMIM10L2Aprovided by HGNC
Official Full Name: small integral membrane protein 10 like 2Aprovided by HGNC
Primary source: HGNC:HGNC:34499
See related: Ensembl:ENSG00000178947 AllianceGenome:HGNC:34499
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LED; LINC0086; LINC00086; LINC00087; SMIM10L2B; NCRNA00086; NCRNA00087
Summary: This gene encodes a highly conserved small protein that contains a conserved motif (DUF4560) and may function as an integral membrane protein. This transcript was also shown to associate with enhancer chromatin and therefore may also function as an RNA to regulate enhancers. [provided by RefSeq, Jan 2017]
Expression: Biased expression in adrenal (RPKM 10.3), brain (RPKM 9.2) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq26.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (135421944..135428075)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (133747687..133753818)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (134555869..134562000)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasma long noncoding RNA LINC00086 expression is significantly lower in gastric cancer (GC) patients than in normal individuals. GC patients with low LINC00086 expression are likely to have larger tumors, lymphatic metastasis, larger TNM stage, and higher carcinoembryonic antigen and carbohydrate antigen 19-9 levels. GC patients with low LINC00086 expression show lower survival rates.
Title: Potential diagnostic and prognostic value of plasma long noncoding RNA LINC00086 and miR-214 expression in gastric cancer.
tumor-suppressive role of LINC0086 in NPC. Low expression of LINC0086 is associated with a poor prognosis of NPC patients. Upregulation of LINC0086 significantly inhibited NPC cancer cell growth and caused apoptosis in vitro and in vivo by targeting miR-214.
Title: Long Noncoding RNA LINC0086 Functions as a Tumor Suppressor in Nasopharyngeal Carcinoma by Targeting miR-214.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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General protein information

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Preferred Names: small integral membrane protein 10-like protein 2A

Names: Small integral membrane protein 10-like protein 2B; lncRNA activator of enhancer domains; long intergenic non-protein coding RNA 86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_203306.3 → NP_976051.1 small integral membrane protein 10-like protein 2A

Status: VALIDATED

Source sequence(s)

AL450472

UniProtKB/Swiss-Prot

P0DMW4, P0DMW5

Related

ENSP00000488643.1, ENST00000417443.3

Conserved Domains (1) summary

pfam15118
Location:21 → 77

DUF4560; Domain of unknown function (DUF4560)