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Envelope surface glycoprotein gp120
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env
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The low mannose-level gp120 induces higher activation of plasmacytoid dendritic cells by upregulation of IFN-alpha, PD-L1, CD40, CCR7, CD80, and CD86 than the high mannose-level gp120 does |
PubMed
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env
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HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells |
PubMed
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env
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The presence of HIV-1 gp120 inhibits the oral mucosal pathogen Porphyromonas gingivalis-induced CD80, CD83, and CD86 upregulation |
PubMed
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env
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Molecular interactions of CD2 with LFA-3 and CD28 with B7-1 in conjunction with TCR occupancy prevent T cells from programmed apoptosis mediated by binding of CD4 to HIV-1 gp120, resulting in increased levels of IL-2 and IL-4 secretion from the T cells |
PubMed
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env
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The binding of HIV-1 gp120 to CD4 molecules on T cells interrupts the sequential cascade of intercellular interactions involving antigen/MHC class II-TCR/CD4, CD40L-CD40, and B71-CD28 |
PubMed
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Nef
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nef
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HIV-1 Nef induces upregulation of CD80, CD83, and CD86 protein expression in a concentration dependent fashion in monocyte derived dendritic cells |
PubMed
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nef
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HIV-1 Nef co-localizes with MHC class I (MHCI), CD80, and CD86 in intracellular compartments by staining assays, and binds to both human CD80 and CD86 using yeast two-hybrid assays |
PubMed
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nef
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HIV-1 Nef downregulates the co-stimulatory molecule CD80 from the cell surface in the human monocytic U937 cell line as well as in mouse macrophages and dendritic cells |
PubMed
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nef
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HIV-1 Nef-induced B-cell differentiation response is suppressed by monoclonal antibodies to cell surface molecule B7, indicating an interaction between Nef and B7 |
PubMed
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nef
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HIV-1 Nef binds to the cytosolic tails of CD80 and CD86 to mediate their internalization |
PubMed
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nef
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Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization |
PubMed
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nef
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HIV-1 Nef relocates cell-surface MHC-I, CD80, and CD86 to intracellular compartments and the Nef-mediated internalization is dependent on mediators of actin polymerization |
PubMed
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Pr55(Gag)
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gag
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Expression of CD80, CD83, CD86, and HLA-DR molecules are significantly downregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs |
PubMed
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gag
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HIV-1 Gag virus-like particles efficiently activate human monocyte-derived dendritic cells (MDDC) and induce MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II |
PubMed
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gag
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HIV-1 Gag virus-like particle-induced monocyte activation is shown by upregulation of molecules involved in antigen presentation (MHC II, CD80, CD86) and cell adhesion (CD54) |
PubMed
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Tat
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tat
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HIV-1 Tat upregulates the expression of MHC and co-stimulatory molecules CD40, CD80, CD83 and CD86 in monocyte-derived dendritic cells, thereby driving T cell-mediated immune responses |
PubMed
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Vpr
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vpr
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HIV-1 Vpr downregulates the expression of several immunologically important molecules including CD40, CD80, CD83, and CD86 co-stimulatory molecules on monocyte-derived macrophage (MDM) and monocyte-derived dendritic cells (MDDC) |
PubMed
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vpr
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HIV-1 Vpr inhibits the expression of co-stimulatory molecules including CD80, CD83, and CD86 at the transcriptional level without altering normal cellular transcription during dendritic cell maturation |
PubMed
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capsid
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gag
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The immobilization of HIV-1 p24 antigen on the micelles upregulates the expression of cell surface markers CD80 and CD86 in human dendritic cells |
PubMed
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