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    ZNF84 zinc finger protein 84 [ Homo sapiens (human) ]

    Gene ID: 7637, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF84provided by HGNC
    Official Full Name
    zinc finger protein 84provided by HGNC
    Primary source
    HGNC:HGNC:13159
    See related
    Ensembl:ENSG00000198040 MIM:618554; AllianceGenome:HGNC:13159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPF2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 7.4), endometrium (RPKM 6.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF84 in Genome Data Viewer
    Location:
    12q24.33; map from Rosati ref via FISH [AFS]
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (133037509..133063299)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (133094846..133120602)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133614095..133639885)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene zinc finger protein 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5134 Neighboring gene ZNF84 divergent transcript Neighboring gene PTP4A1 pseudogene 2 Neighboring gene MPRA-validated peak2056 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7399 Neighboring gene zinc finger protein 140 Neighboring gene zinc finger protein 891 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26217 Neighboring gene ribosomal protein L23a pseudogene 67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Assignment to chromosome 12q24.33, gene organization and splicing of the human KRAB/FPB containing zinc finger gene ZNF84. Rosati M, et al. Cytogenet Cell Genet, 2001. PMID 11856868
    2. Increased ZNF84 expression in cervical cancer. Li P, et al. Arch Gynecol Obstet, 2018 Jun. PMID 29610946
    3. Members of the zinc finger protein gene family sharing a conserved N-terminal module. Rosati M, et al. Nucleic Acids Res, 1991 Oct 25. PMID 1945843, Free PMC Article
    4. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. Bellefroid EJ, et al. DNA, 1989 Jul-Aug. PMID 2505992
    5. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF84 expression was increased in CC [cervical cancer ] tissues and associated with tumor size. ZNF84 promoted cell proliferation which might involve Akt signal.
      Title: Increased ZNF84 expression in cervical cancer.
    2. FISH assignment to chromosome 12q24.33; gene organization and splicing
      Title: Assignment to chromosome 12q24.33, gene organization and splicing of the human KRAB/FPB containing zinc finger gene ZNF84.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 84
    Names
    zinc finger protein HPF2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127372.3 → NP_001120844.1  zinc finger protein 84

      See identical proteins and their annotated locations for NP_001120844.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC073911
      Consensus CDS
      CCDS31940.1
      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Conserved Domains (4) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:317 → 724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278 → 302
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001289971.2 → NP_001276900.1  zinc finger protein 84

      See identical proteins and their annotated locations for NP_001276900.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC073911
      Consensus CDS
      CCDS31940.1
      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Related
      ENSP00000445549.1, ENST00000539354.6
      Conserved Domains (4) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:317 → 724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278 → 302
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001289972.2 → NP_001276901.1  zinc finger protein 84

      See identical proteins and their annotated locations for NP_001276901.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC073911
      Consensus CDS
      CCDS31940.1
      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Related
      ENSP00000331465.7, ENST00000327668.11
      Conserved Domains (4) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:317 → 724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278 → 302
      zf-H2C2_2; Zinc-finger double domain

    4. NM_003428.6 → NP_003419.3  zinc finger protein 84

      See identical proteins and their annotated locations for NP_003419.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC073911
      Consensus CDS
      CCDS31940.1
      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Related
      ENSP00000376133.2, ENST00000392319.6
      Conserved Domains (4) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:317 → 724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278 → 302
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      133037509..133063299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429505.1 → XP_047285461.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    2. XM_047429511.1 → XP_047285467.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    3. XM_047429507.1 → XP_047285463.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    4. XM_047429504.1 → XP_047285460.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    5. XM_011534832.2 → XP_011533134.1  zinc finger protein 84 isoform X1

      See identical proteins and their annotated locations for XP_011533134.1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Conserved Domains (4) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:317 → 724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278 → 302
      zf-H2C2_2; Zinc-finger double domain

    6. XM_047429506.1 → XP_047285462.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    7. XM_005266186.2 → XP_005266243.1  zinc finger protein 84 isoform X1

      See identical proteins and their annotated locations for XP_005266243.1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Conserved Domains (4) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:317 → 724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278 → 302
      zf-H2C2_2; Zinc-finger double domain

    8. XM_005266185.2 → XP_005266242.1  zinc finger protein 84 isoform X1

      See identical proteins and their annotated locations for XP_005266242.1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
      Related
      ENSP00000437949.1, ENST00000543758.5
      Conserved Domains (4) summary
      smart00349
      Location:9 → 68
      KRAB; krueppel associated box
      COG5048
      Location:317 → 724
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278 → 302
      zf-H2C2_2; Zinc-finger double domain

    9. XM_047429508.1 → XP_047285464.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    10. XM_047429510.1 → XP_047285466.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    11. XM_047429509.1 → XP_047285465.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      133094846..133120602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373140.1 → XP_054229115.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    2. XM_054373138.1 → XP_054229113.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    3. XM_054373136.1 → XP_054229111.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    4. XM_054373139.1 → XP_054229114.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    5. XM_054373137.1 → XP_054229112.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    6. XM_054373135.1 → XP_054229110.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    7. XM_054373143.1 → XP_054229118.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    8. XM_054373142.1 → XP_054229117.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18

    9. XM_054373141.1 → XP_054229116.1  zinc finger protein 84 isoform X1

      UniProtKB/Swiss-Prot
      B2RAK5, D3DXJ1, P51523, Q3ZCV9, Q5D057, Q86XU8, Q9NNX7, Q9UC17, Q9UC18
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51523.2 GenPept UniProtKB/Swiss-Prot:P51523

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