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    DTX3L deltex E3 ubiquitin ligase 3L [ Homo sapiens (human) ]

    Gene ID: 151636, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DTX3Lprovided by HGNC
    Official Full Name
    deltex E3 ubiquitin ligase 3Lprovided by HGNC
    Primary source
    HGNC:HGNC:30323
    See related
    Ensembl:ENSG00000163840 MIM:613143; AllianceGenome:HGNC:30323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BBAP; RNF143
    Summary
    Enables several functions, including STAT family protein binding activity; histone H4K91 ubiquitin ligase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization; and protein ubiquitination. Located in several cellular components, including early endosome; lysosome; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in appendix (RPKM 14.2), spleen (RPKM 13.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DTX3L in Genome Data Viewer
    Location:
    3q21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (122564338..122575203)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (125283584..125294443)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122283185..122294050)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984000 Neighboring gene uncharacterized LOC105374071 Neighboring gene Sharpr-MPRA regulatory region 13157 Neighboring gene poly(ADP-ribose) polymerase family member 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14643 Neighboring gene poly(ADP-ribose) polymerase family member 15 Neighboring gene poly(ADP-ribose) polymerase family member 14 pseudogene Neighboring gene uncharacterized LOC124909419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20380 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:122353940-122355139 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids. Zhu K, et al. Nucleic Acids Res, 2024 Jan 25. PMID 38000390, Free PMC Article
    2. Fold of the conserved DTC domain in Deltex proteins. Obiero J, et al. Proteins, 2012 May. PMID 22411408
    3. DTX3L is upregulated in glioma and is associated with glioma progression. Xu P, et al. Int J Mol Med, 2017 Aug. PMID 28627634
    4. Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells. Shen Y, et al. Tumour Biol, 2017 Jun. PMID 28653881
    5. Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L. Zhu K, et al. EMBO Rep, 2024 Oct. PMID 39242775, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L.
      Title: Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L.
    2. DTX3L Accelerates Pancreatic cancer Progression via FAK/PI3K/AKT Axis.
      Title: DTX3L Accelerates Pancreatic cancer Progression via FAK/PI3K/AKT Axis.
    3. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids.
      Title: DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids.
    4. DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity in pancreatic cancer.
      Title: DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity in pancreatic cancer.
    5. The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.
      Title: The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.
    6. Immunohistochemical analysis demonstrated that DTX3L was highly expressed in the glioma tissues and its level was correlated with the grade of malignancy. Multivariate analysis revealed the association between high expression of DTX3L and the poor prognosis of glioma patients. In addition, knockdown of DTX3L by siRNA transfection increased glioma cell apoptosis.
      Title: DTX3L is upregulated in glioma and is associated with glioma progression.
    7. Dtx3L heterodimerization with Parp9 enables NAD(+) and poly(ADP-ribose) regulation of E3 activity.
      Title: Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.
    8. we also found that DTX3L expression was regulated by focal adhesion kinase. Taken together, the results of this study show that DTX3L plays an important role in the proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells and as such may play a key role in the development of multiple myeloma.
      Title: Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells.
    9. A novel role for the really interesting new gene-domain E3 ubiquitin ligase deltex-3-like (DTX3L) in regulating CXCR4 sorting from endosomes to lysosomes.
      Title: The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
    10. The present study further suggests that the combined targeted inhibition of STAT1, ARTD8, ARTD9 and/or DTX3L could increase the efficacy of chemotherapy or radiation treatment in prostate and other high-risk tumor types with an increased STAT1 signaling.
      Title: DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A mega-analysis of genome-wide association studies for major depressive disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables STAT family protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H4K91 ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone ubiquitin ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein ADP-ribosyltransferase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair-dependent chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of chromatin binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to early endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of receptor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase DTX3L
    Names
    B-lymphoma- and BAL-associated protein
    RING-type E3 ubiquitin transferase DTX3L
    deltex 3 like, E3 ubiquitin ligase
    deltex 3-like
    rhysin-2
    rhysin2
    NP_612144.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138287.3 → NP_612144.1  E3 ubiquitin-protein ligase DTX3L

      See identical proteins and their annotated locations for NP_612144.1

      Status: VALIDATED

      Source sequence(s)
      AC092908
      Consensus CDS
      CCDS3015.1
      UniProtKB/Swiss-Prot
      B3KWH6, Q53ZZ3, Q5MJP7, Q8TDB6
      Related
      ENSP00000296161.4, ENST00000296161.9
      Conserved Domains (3) summary
      cd09633
      Location:608 → 738
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd12300
      Location:8 → 86
      RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
      cd16712
      Location:560 → 600
      RING-HC_DTX3L; RING finger, HC subclass, found in protein Deltex-3-like (DTX3L) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      122564338..122575203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      125283584..125294443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDB6.1 GenPept UniProtKB/Swiss-Prot:Q8TDB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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