NME2 NME/NM23 nucleoside diphosphate kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NME2provided by HGNC
Official Full Name: NME/NM23 nucleoside diphosphate kinase 2provided by HGNC
Primary source: HGNC:HGNC:7850
See related: Ensembl:ENSG00000243678 MIM:156491; AllianceGenome:HGNC:7850
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
Summary: Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Expression: Ubiquitous expression in colon (RPKM 115.3), fat (RPKM 91.9) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 17q21.33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (51165536..51171744)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (52032848..52039047)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (49242897..49249105)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
Title: Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells.
Title: Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells.
Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
Title: Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.
Title: The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.
Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding.
Title: Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding.
NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.
Title: NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.
miR-645 was up-regulated in osteosarcoma tissues and could promote osteosarcoma cell migration through directly inhibiting the tumor suppressor NME2
Title: MicroRNA-645 promotes metastasis of osteosarcoma via targeting tumor suppressor NM23 nucleoside diphosphate kinase 2.
Study in cultured HUVEC cells demonstrated that the upregulation of ANG2 upon NDPK-B deficiency (siRNA knockdown) is driven by O-GlcNAcylation of FOXO1 and provide evidence for a central role of protein O-GlcNAcylation in NDPK-B associated vascular damage and point to the hexosamine pathway as an important target in retinal vasoregression.
Title: O-GlcNAcylation of FoxO1 mediates nucleoside diphosphate kinase B deficiency induced endothelial damage.
Study reports that NME2 is an oncogene in osteosarcoma (OS) that is associated with its clinicopathologic features. Downregulation of NME2 could reduce the proliferation of OS cells and arrest the OS cell cycle in the G2/M phase. The deregulation of NME2 enhanced the expression of c-Myc and affected the proliferation of osteosarcoma.
Title: Nucleoside diphosphate kinase B promotes osteosarcoma proliferation through c-Myc.
NME2 mediates chemoresistance to 5-FU in CRC
Title: Nucleoside diphosphate kinase 2 confers acquired 5-fluorouracil resistance in colorectal cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of NME/NM23 nucleoside diphosphate kinase 2 (NME2) in human primary T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80623 (e-PCR)
- UniSTS:84024

RH70845 (e-PCR)
- UniSTS:19132

G43341 (e-PCR)
- UniSTS:94942

Readthrough NME1-NME2

Readthrough gene: NME1-NME2, Included gene: NME1

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables G-quadruplex DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables GDP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside triphosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-histidine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
NOT located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: nucleoside diphosphate kinase B

Names: HEL-S-155an; NDP kinase B; c-myc purine-binding transcription factor PUF; c-myc transcription factor; epididymis secretory sperm binding protein Li 155an; histidine protein kinase NDKB; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in; nucleotide diphosphate kinase B

NP_001018147.1

EC 2.7.13.3

EC 2.7.4.6

NP_001018148.1

EC 2.7.13.3

EC 2.7.4.6

NP_001018149.1

EC 2.7.13.3

EC 2.7.4.6

NP_001185611.1

EC 2.7.13.3

EC 2.7.4.6

NP_002503.1

EC 2.7.13.3

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001018137.3 → NP_001018147.1 nucleoside diphosphate kinase B isoform a

See identical proteins and their annotated locations for NP_001018147.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).

Source sequence(s)

CA307456, CK023920

Consensus CDS

CCDS11580.1

UniProtKB/Swiss-Prot

A8MWA3, O60361, P22392, Q1WM23, Q6LCT6

UniProtKB/TrEMBL

Q6FHN3

Related

ENSP00000426976.2, ENST00000514264.6

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
NM_001018138.1 → NP_001018148.1 nucleoside diphosphate kinase B isoform a

See identical proteins and their annotated locations for NP_001018148.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).

Source sequence(s)

BC002476, BF058708

Consensus CDS

CCDS11580.1

UniProtKB/Swiss-Prot

A8MWA3, O60361, P22392, Q1WM23, Q6LCT6

UniProtKB/TrEMBL

Q6FHN3

Related

ENSP00000376886.1, ENST00000393190.4

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
NM_001018139.2 → NP_001018149.1 nucleoside diphosphate kinase B isoform a

See identical proteins and their annotated locations for NP_001018149.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).

Source sequence(s)

BM556410

Consensus CDS

CCDS11580.1

UniProtKB/Swiss-Prot

A8MWA3, O60361, P22392, Q1WM23, Q6LCT6

UniProtKB/TrEMBL

Q6FHN3

Related

ENSP00000426901.1, ENST00000503064.5

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
NM_001198682.2 → NP_001185611.1 nucleoside diphosphate kinase B isoform b

See identical proteins and their annotated locations for NP_001185611.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.

Source sequence(s)

CB242387, CN267160, DB454073

Consensus CDS

CCDS74107.1

UniProtKB/TrEMBL

F6XY72

Related

ENSP00000376880.4, ENST00000393183.7

Conserved Domains (1) summary

cl00335
Location:5 → 76

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
NM_002512.4 → NP_002503.1 nucleoside diphosphate kinase B isoform a

See identical proteins and their annotated locations for NP_002503.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-4 encode the same isoform.

Source sequence(s)

BC095458, BF034471, DB454073

Consensus CDS

CCDS11580.1

UniProtKB/Swiss-Prot

A8MWA3, O60361, P22392, Q1WM23, Q6LCT6

UniProtKB/TrEMBL

Q6FHN3

Related

ENSP00000421064.1, ENST00000512737.6

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional