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    Cebpz CCAAT/enhancer binding protein zeta [ Mus musculus (house mouse) ]

    Gene ID: 12607, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cebpzprovided by MGI
    Official Full Name
    CCAAT/enhancer binding protein zetaprovided by MGI
    Primary source
    MGI:MGI:109386
    See related
    Ensembl:ENSMUSG00000024081 AllianceGenome:MGI:109386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cbf; CBF2
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of CCAAT-binding activity factor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; bone; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 12.2), placenta adult (RPKM 6.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cebpz in Genome Data Viewer
    Location:
    17 E3; 17 49.65 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79226432..79244499, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78919003..78937070, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 26637 Neighboring gene sulfotransferase family, cytosolic, 6B, member 1 Neighboring gene STARR-seq mESC enhancer starr_43273 Neighboring gene STARR-positive B cell enhancer ABC_E8698 Neighboring gene CCAAT/enhancer binding protein zeta, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E5629 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene protein kinase D3 Neighboring gene predicted gene, 41622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The CCAAT-binding proteins CP1 and NF-I cooperate with ATF-2 in the transcription of the fibronectin gene. Alonso CR, et al. J Biol Chem, 1996 Sep 6. PMID 8703044
    2. Cloning and characterization of mouse CCAAT binding factor. Hoeppner MA, et al. Nucleic Acids Res, 1996 Mar 15. PMID 8604343, Free PMC Article
    3. The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Paces-Fessy M, et al. Biochem J, 2004 Mar 1. PMID 14611647, Free PMC Article
    4. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36087

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CCAAT/enhancer-binding protein zeta
    Names
    CCAAT-binding factor
    CCAAT-box-binding transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024806.2 → NP_001019977.1  CCAAT/enhancer-binding protein zeta

      See identical proteins and their annotated locations for NP_001019977.1

      Status: VALIDATED

      Source sequence(s)
      AI848081, AK017537, AK158771, BY077658
      Consensus CDS
      CCDS28981.1
      UniProtKB/Swiss-Prot
      P53569, Q3TXW5, Q3TYA8, Q3UWQ7
      UniProtKB/TrEMBL
      A0A0R4J046
      Related
      ENSMUSP00000024885.9, ENSMUST00000024885.10
      Conserved Domains (3) summary
      COG5593
      Location:179 → 987
      COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]
      pfam03914
      Location:523 → 732
      CBF; CBF/Mak21 family
      cl17018
      Location:273 → 436
      FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      79226432..79244499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523558.5 → XP_006523621.1  CCAAT/enhancer-binding protein zeta isoform X1

      Conserved Domains (2) summary
      pfam03914
      Location:1 → 181
      CBF; CBF/Mak21 family
      pfam04147
      Location:275 → 435
      Nop14; Nop14-like family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_009882.2: Suppressed sequence

      Description
      NM_009882.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53569.2 GenPept UniProtKB/Swiss-Prot:P53569

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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