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    OR2L13 olfactory receptor family 2 subfamily L member 13 [ Homo sapiens (human) ]

    Gene ID: 284521, updated on 14-Nov-2024

    Summary

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    Official Symbol
    OR2L13provided by HGNC
    Official Full Name
    olfactory receptor family 2 subfamily L member 13provided by HGNC
    Primary source
    HGNC:HGNC:19578
    See related
    Ensembl:ENSG00000196071 AllianceGenome:HGNC:19578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR2L14
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See OR2L13 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (247937177..248101163)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247363114..247527286)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248100479..248264465)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AJ member 1 Neighboring gene CDC like kinase 3 pseudogene 2 Neighboring gene olfactory receptor family 2 subfamily X member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily L member 8 Neighboring gene olfactory receptor family 2 subfamily AK member 2 Neighboring gene olfactory receptor family 2 subfamily L member 9 pseudogene Neighboring gene olfactory receptor family 2 subfamily L member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily L member 6 pseudogene Neighboring gene olfactory receptor family 2 subfamily L member 5 Neighboring gene uncharacterized LOC105373275 Neighboring gene olfactory receptor family 2 subfamily L member 2 Neighboring gene olfactory receptor family 2 subfamily L member 3 Neighboring gene olfactory receptor family 2 subfamily T member 32 pseudogene Neighboring gene olfactory receptor family 2 subfamily M member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily M member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. Morrell CN, et al. J Clin Invest, 2022 May 2. PMID 35324479, Free PMC Article
    2. Maternal 5(m)CpG Imprints at the PARD6G-AS1 and GCSAML Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues. de Sá Machado Araújo G, et al. Front Genet, 2018. PMID 29545821, Free PMC Article
    3. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. Naz RK, et al. J Reprod Immunol, 2010 Jan. PMID 19945174, Free PMC Article
    4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms.
      Title: Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms.
    2. RNA-Seq evidence of testis-specific monoallelic expression of OR2L13, located 419 kb downstream of the GCSAML somatic (secondary), imprinted differentially methylated region (iDMR). OR2L13 has a predicted CGI-bearing allelically methylated region overlapping the promoter region in blood, spleen, lung, liver, esophagus, and brain, but hypomethylated in gamete, blastocyst, placenta, thymus, and spinal cord methylomes.
      Title: Maternal 5(m)CpG Imprints at the PARD6G-AS1 and GCSAML Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40047

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 2L13
    Names
    olfactory receptor 2L14
    olfactory receptor, family 2, subfamily L, member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304535.3 → NP_001291464.1  olfactory receptor 2L13

      See identical proteins and their annotated locations for NP_001291464.1

      Status: VALIDATED

      Source sequence(s)
      AC099571, AL513488
      Consensus CDS
      CCDS1637.1
      UniProtKB/Swiss-Prot
      Q5VUR5, Q8N349
      UniProtKB/TrEMBL
      A0A126GW96
      Conserved Domains (1) summary
      cd15421
      Location:37 → 300
      7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001395936.1 → NP_001382865.1  olfactory receptor 2L13

      Status: VALIDATED

      Source sequence(s)
      AL513488
      Consensus CDS
      CCDS1637.1
      UniProtKB/Swiss-Prot
      Q5VUR5, Q8N349
      UniProtKB/TrEMBL
      A0A126GW96
      Related
      ENSP00000350836.2, ENST00000358120.4
      Conserved Domains (1) summary
      cd15421
      Location:37 → 300
      7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_175911.5 → NP_787107.1  olfactory receptor 2L13

      See identical proteins and their annotated locations for NP_787107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC099571, AL513488
      Consensus CDS
      CCDS1637.1
      UniProtKB/Swiss-Prot
      Q5VUR5, Q8N349
      UniProtKB/TrEMBL
      A0A126GW96
      Conserved Domains (1) summary
      cd15421
      Location:37 → 300
      7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      247937177..248101163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544169.3 → XP_011542471.1  olfactory receptor 2L13 isoform X1

      See identical proteins and their annotated locations for XP_011542471.1

      UniProtKB/Swiss-Prot
      Q5VUR5, Q8N349
      UniProtKB/TrEMBL
      A0A126GW96
      Conserved Domains (1) summary
      cd15421
      Location:37 → 300
      7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      247363114..247527286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336108.1 → XP_054192083.1  olfactory receptor 2L13 isoform X1

      UniProtKB/Swiss-Prot
      Q5VUR5, Q8N349
      UniProtKB/TrEMBL
      A0A126GW96
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N349.1 GenPept UniProtKB/Swiss-Prot:Q8N349

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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