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    Mcm10 minichromosome maintenance 10 replication initiation factor [ Mus musculus (house mouse) ]

    Gene ID: 70024, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mcm10provided by MGI
    Official Full Name
    minichromosome maintenance 10 replication initiation factorprovided by MGI
    Primary source
    MGI:MGI:1917274
    See related
    Ensembl:ENSMUSG00000026669 AllianceGenome:MGI:1917274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410041F14Rik; C330019M07Rik
    Summary
    Enables enzyme binding activity. Acts upstream of or within cell population proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nuclear replication fork. Is expressed in several structures, including adrenal gland; brain; gonad; gut; and immune system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 7.2), CNS E11.5 (RPKM 6.2) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mcm10 in Genome Data Viewer
    Location:
    2 A1; 2 3.12 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (4995535..5017602, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (4990724..5012791, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03551 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene upper zone of growth plate and cartilage matrix associated Neighboring gene STARR-positive B cell enhancer ABC_E3357 Neighboring gene optineurin Neighboring gene predicted gene, 39755

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality. Lim HJ, et al. Biochim Biophys Acta, 2011 Oct. PMID 21693137
    2. Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Elliott EN, et al. Development, 2015 Jun 15. PMID 26023099, Free PMC Article
    3. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439
    4. Atypical E2F repressors and activators coordinate placental development. Ouseph MM, et al. Dev Cell, 2012 Apr 17. PMID 22516201, Free PMC Article
    5. The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Park JY, et al. Development, 2016 Jan 1. PMID 26657772, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic evidence for an essential and non-redundant physiological role of MCM10 during murine peri-implantation development.
      Title: Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein MCM10 homolog
    Names
    minichromosome maintenance deficient 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305259.1 → NP_001292188.1  protein MCM10 homolog

      See identical proteins and their annotated locations for NP_001292188.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC064314
      Consensus CDS
      CCDS15662.1
      UniProtKB/Swiss-Prot
      Q0VBD2, Q505F3, Q8BMJ1, Q8BYA7
      Related
      ENSMUSP00000100050.2, ENSMUST00000102985.8
      Conserved Domains (2) summary
      pfam09329
      Location:398 → 443
      zf-primase; Primase zinc finger
      pfam09332
      Location:544 → 883
      Mcm10; Mcm10 replication factor

    2. NM_027290.3 → NP_081566.2  protein MCM10 homolog

      See identical proteins and their annotated locations for NP_081566.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK030780, BC094576, BE951862
      Consensus CDS
      CCDS15662.1
      UniProtKB/Swiss-Prot
      Q0VBD2, Q505F3, Q8BMJ1, Q8BYA7
      Related
      ENSMUSP00000027980.8, ENSMUST00000027980.8
      Conserved Domains (2) summary
      pfam09329
      Location:398 → 443
      zf-primase; Primase zinc finger
      pfam09332
      Location:544 → 883
      Mcm10; Mcm10 replication factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      4995535..5017602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162558.1 → XP_036018451.1  protein MCM10 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q0VBD2, Q505F3, Q8BMJ1, Q8BYA7
      Conserved Domains (2) summary
      pfam09329
      Location:398 → 443
      zf-primase; Primase zinc finger
      pfam09332
      Location:544 → 883
      Mcm10; Mcm10 replication factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VBD2.1 GenPept UniProtKB/Swiss-Prot:Q0VBD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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