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    achi achintya [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36373, updated on 28-Oct-2024

    Summary

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    Official Symbol
    achiprovided by FlyBase
    Official Full Name
    achintyaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033749
    Locus tag
    Dmel_CG8819
    See related
    AllianceGenome:FB:FBgn0033749
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ach; Achi; achi/vis; CG8819; Dmel\CG8819; dTGIF; dTGIFa; dTGIFb; TGIF; vis; zaa
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of DNA-templated transcription and spermatogenesis. Located in nucleus. Is expressed in several structures, including antennal anlage; ganglia; gonad; head epidermis primordium; and male germline cell. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to human TGIF1 (TGFB induced factor homeobox 1) and TGIF2 (TGFB induced factor homeobox 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See achi in Genome Data Viewer
    Location:
    49A10-49A10; 2-67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12511534..12515062, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8399039..8402567, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene fused lobes Neighboring gene stanley-cup Neighboring gene vismay Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila TGIF proteins are transcriptional activators. Hyman CA, et al. Mol Cell Biol, 2003 Dec. PMID 14645536, Free PMC Article
    2. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. Xia S, et al. PLoS Genet, 2021 Jul. PMID 34242211, Free PMC Article
    3. Dynamics and stage-specificity of between-population gene expression divergence in the Drosophila melanogaster larval fat body. Glaser-Schmitt A, et al. PLoS Genet, 2023 Apr. PMID 37099612, Free PMC Article
    4. Transgenic analyses of TGIF family proteins in Drosophila imply their role in cell growth. Wang Y, et al. J Genet Genomics, 2008 Aug. PMID 18721782
    5. Molecular mechanisms of gene regulation during Drosophila spermatogenesis. White-Cooper H. Reproduction, 2010 Jan. PMID 19755484

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    achintya
    Names
    CG8819-PA
    CG8819-PC
    CG8819-PD
    achi-PA
    achi-PC
    achi-PD
    zuker-aly-like a

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12511534..12515062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165911.2 → NP_725182.1  achintya, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725182.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR08
      Related
      FBpp0087054
      Conserved Domains (1) summary
      pfam05920
      Location:111 → 150
      Homeobox_KN; Homeobox KN domain

    2. NM_165912.2 → NP_725183.1  achintya, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z916
      Related
      FBpp0087053
      Conserved Domains (1) summary
      pfam05920
      Location:111 → 150
      Homeobox_KN; Homeobox KN domain

    3. NM_001299423.1 → NP_001286352.1  achintya, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z916
      Conserved Domains (1) summary
      pfam05920
      Location:111 → 150
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z916 A1Z916
    Q7JR08 Q7JR08

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