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    Tctp Translationally controlled tumor protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41341, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tctpprovided by FlyBase
    Official Full Name
    Translationally controlled tumor proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037874
    Locus tag
    Dmel_CG4800
    See related
    AllianceGenome:FB:FBgn0037874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4800; Dmel\CG4800; dTCTP; TCTP
    Summary
    Enables guanyl-nucleotide exchange factor activity and protein kinase activator activity. Involved in several processes, including cellular response to gamma radiation; mitotic DNA damage checkpoint signaling; and positive regulation of cell size. Located in nucleus and polytene chromosome. Is expressed in adult head and adult heart. Orthologous to several human genes including TPT1P8 (TPT1 pseudogene 8) and TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See Tctp in Genome Data Viewer
    Location:
    86D8-86D8; 3-50 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11210247..11211898)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7035969..7037004)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene curled Neighboring gene Succinate dehydrogenase, subunit C Neighboring gene Zinc transporter 86D Neighboring gene Ribosomal protein S25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and clinical role of TCTP in epithelial ovarian cancer. Chen C, et al. J Mol Histol, 2015 Apr. PMID 25564355
    2. Analysis of translation control tumor protein related to deltamethrin stress in Drosophila kc cells. Ying X, et al. Chemosphere, 2019 Sep. PMID 31146137
    3. Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies. Choi KW, et al. Results Probl Cell Differ, 2017. PMID 29149408
    4. The functional link between TCTP and Drsl1 in deltamethrin-stressed Drosophila Kc cells. Zhang M, et al. Gene, 2023 Feb 15. PMID 36464172
    5. Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects. Gao J, et al. J Zhejiang Univ Sci B, 2022 Aug 15. PMID 35953758, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
      Title: Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
    2. Topoisomerase II is regulated by translationally controlled tumor protein for cell survival during organ growth in Drosophila.
      Title: Topoisomerase II is regulated by translationally controlled tumor protein for cell survival during organ growth in Drosophila.
    3. Regulation of epithelial integrity and organ growth by Tctp and Coracle in Drosophila.
      Title: Regulation of epithelial integrity and organ growth by Tctp and Coracle in Drosophila.
    4. REVIEW: Tctp functions in Drosophila and discuss their implications in cancer
      Title: Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies.
    5. TCTP may promote the progression of epithelial ovarian cancer and reduce the sensitiveness of HO8910 cells to cisplatin.
      Title: Expression and clinical role of TCTP in epithelial ovarian cancer.
    6. TCTP has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster
      Title: TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster.
    7. plant AtTCTP can fully rescue cell proliferation defects in Drosophila loss of function for dTCTP
      Title: Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants.
    8. Drosophila TCTP (dTCTP) displays GEF activity to Rheb and is essential for Rheb activation in organ growth
      Title: To cease or to proliferate: new insights into TCTP function from a Drosophila study.
    9. Our studies identify TCTP as a direct regulator of Rheb and a potential therapeutic target for tuberous sclerosis disease.
      Title: Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic intra-S DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translationally controlled tumor protein
    Names
    CG4800-PA
    CG4800-PB
    Tctp-PA
    Tctp-PB
    translationally controlled tumor protein ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11210247..11211898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316502.1 → NP_001303431.1  translationally controlled tumor protein, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q49UC2, Q95TW0, Q9VGS2
      UniProtKB/TrEMBL
      A0A126GUT1, S5PU30
      Conserved Domains (1) summary
      pfam00838
      Location:1 → 167
      TCTP; Translationally controlled tumor protein

    2. NM_141791.3 → NP_650048.1  translationally controlled tumor protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q49UC2, Q95TW0, Q9VGS2
      UniProtKB/TrEMBL
      A0A126GUT1, S5PU30
      Related
      FBpp0081820
      Conserved Domains (1) summary
      pfam00838
      Location:1 → 167
      TCTP; Translationally controlled tumor protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GUT1 A0A126GUT1
    Q9VGS2.1 Q9VGS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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