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    Hsc70-3 Heat shock protein 70 cognate 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32133, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Hsc70-3provided by FlyBase
    Official Full Name
    Heat shock protein 70 cognate 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0001218
    Locus tag
    Dmel_CG4147
    See related
    AllianceGenome:FB:FBgn0001218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A4V4C4_DROME; anon-WO0138581.7; bip; Bip; BiP; BIP; CG1579; CG4147; dBip; dBiP; dhsc70; Dmel\CG4147; dmHsc72; grp78; Grp78; GRP78; GRP87/Bip; Hsc-3; HSC-70; Hsc-70-3; hsc3; Hsc3; HSC3; Hsc3-BiP/GRP78; Hsc3p; hsc70; Hsc70; HSC70; hsc70-3; HSC70-3; Hsc70.3; hsc72; Hsc73; Hsp-c3; HSP70; HSP70er1; HSP7C_DROME; HSPA5; l(1)G0102; l(1)G0111; l(1)G0292; l(1)G0341; l(1)G0407; l(1)G0466
    Summary
    Enables ATP hydrolysis activity. Involved in several processes, including intestinal stem cell homeostasis; negative regulation of organ growth; and positive regulation of hippo signaling. Located in endoplasmic reticulum and extracellular space. Part of endoplasmic reticulum chaperone complex. Is expressed in adult head; adult heart; spermatozoon; and wing disc. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See Hsc70-3 in Genome Data Viewer
    Location:
    10E3-10E4; 1-36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11801696..11807117, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11695729..11701150, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44962 Neighboring gene karl Neighboring gene Casein kinase II beta subunit Neighboring gene uncharacterized protein Neighboring gene rudhira

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila. Fernandez-Funez P, et al. Proc Natl Acad Sci U S A, 2016 Aug 30. PMID 27531960, Free PMC Article
    2. A role for the molecular chaperone protein BiP/GRP78 in Drosophila sleep homeostasis. Naidoo N, et al. Sleep, 2007 May. PMID 17552370
    3. AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models. Hong H, et al. J Biol Chem, 2019 Feb 22. PMID 30593503, Free PMC Article
    4. Heavy chain dimers as well as complete antibodies are efficiently formed and secreted from Drosophila via a BiP-mediated pathway. Kirkpatrick RB, et al. J Biol Chem, 1995 Aug 25. PMID 7649989
    5. Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Preissler S, et al. Elife, 2020 Dec 9. PMID 33295873, Free PMC Article

    See all (260) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-transporting ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of endoplasmic reticulum chaperone complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heat shock protein 70 cognate 3
    Names
    70 kDa heat shock protein, endoplasmic reticulum 1
    CG4147-PA
    CG4147-PB
    CG4147-PC
    CG4147-PD
    CG4147-PE
    GRP78
    Hsc70-3-PA
    Hsc70-3-PB
    Hsc70-3-PC
    Hsc70-3-PD
    Hsc70-3-PE
    glucose-regulated protein 78kD/binding immunoglobulin protein
    heat shock 70-kDa protein cognate 3
    heat shock cognate protein 3
    heat shock protein cognate 3
    heat shock protein cognate 70-3
    heat shock protein cognate 72
    heat-shock cognate 70-3
    immunoglobulin binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11801696..11807117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078577.3 → NP_511132.2  heat shock protein 70 cognate 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511132.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3
      UniProtKB/TrEMBL
      F3YDH0
      Related
      FBpp0073445
      Conserved Domains (2) summary
      cd10241
      Location:29 → 403
      HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
      PTZ00009
      Location:32 → 643
      PTZ00009; heat shock 70 kDa protein; Provisional

    2. NM_167306.2 → NP_727563.1  heat shock protein 70 cognate 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3
      UniProtKB/TrEMBL
      F3YDH0
      Related
      FBpp0073446
      Conserved Domains (2) summary
      cd10241
      Location:29 → 403
      HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
      PTZ00009
      Location:32 → 643
      PTZ00009; heat shock 70 kDa protein; Provisional

    3. NM_167308.2 → NP_727565.1  heat shock protein 70 cognate 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727565.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3
      UniProtKB/TrEMBL
      F3YDH0
      Related
      FBpp0073447
      Conserved Domains (2) summary
      cd10241
      Location:29 → 403
      HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
      PTZ00009
      Location:32 → 643
      PTZ00009; heat shock 70 kDa protein; Provisional

    4. NM_167307.2 → NP_727564.1  heat shock protein 70 cognate 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3
      UniProtKB/TrEMBL
      F3YDH0
      Related
      FBpp0073448
      Conserved Domains (2) summary
      cd10241
      Location:29 → 403
      HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
      PTZ00009
      Location:32 → 643
      PTZ00009; heat shock 70 kDa protein; Provisional

    5. NM_001298210.1 → NP_001285139.1  heat shock protein 70 cognate 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3
      UniProtKB/TrEMBL
      F3YDH0
      Conserved Domains (2) summary
      cd10241
      Location:29 → 403
      HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
      PTZ00009
      Location:32 → 643
      PTZ00009; heat shock 70 kDa protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F3YDH0 F3YDH0
    P29844.2 P29844

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