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    dlt discs lost [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46719, updated on 28-Oct-2024

    Summary

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    Official Symbol
    dltprovided by FlyBase
    Official Full Name
    discs lostprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024510
    Locus tag
    Dmel_CG32315
    See related
    AllianceGenome:FB:FBgn0024510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1977; CG32315; Discs lost; Dlt; DLT; Dmel\CG32315; dre1; l(3)04276; l(3)62Ba; l(3)dre1; Van
    Summary
    Involved in imaginal disc morphogenesis; olfactory behavior; and regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including ectoderm; embryonic/larval salivary gland; furrow canal; gut section; and spermatozoon. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia and congenital dyserythropoietic anemia type Ia. Orthologous to human CDAN1 (codanin 1). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

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    See dlt in Genome Data Viewer
    Location:
    62B4-62B4; 3-1.0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1789631..1795328, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1789631..1795328, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene alpha Spectrin Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene antisense RNA:CR45834 Neighboring gene antisense RNA:CR45818 Neighboring gene Cell division cycle 37 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetic architecture of quantitative traits: lessons from Drosophila. Mackay TF. Curr Opin Genet Dev, 2004 Jun. PMID 15172667
    2. DPATJ plays a role in retinal morphogenesis and protects against light-dependent degeneration of photoreceptor cells in the Drosophila eye. Richard M, et al. Dev Dyn, 2006 Apr. PMID 16245332
    3. Discs-Large and Strabismus are functionally linked to plasma membrane formation. Lee OK, et al. Nat Cell Biol, 2003 Nov. PMID 14562058, Free PMC Article
    4. Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior. Fanara JJ, et al. Genetics, 2002 Nov. PMID 12454076, Free PMC Article
    5. Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster. Lee JK, et al. J Cell Biol, 1993 Dec. PMID 8276898, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of a polarized epithelium TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in olfactory behavior IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    discs lost
    Names
    CG32315-PA
    dlt-PA
    lethal(3)62Ba
    vanaso

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1789631..1795328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167916.3 → NP_728672.1  discs lost [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728672.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T626, Q8T627, Q9W084
      Related
      FBpp0072673
      Conserved Domains (1) summary
      pfam15296
      Location:788 → 908
      Codanin-1_C; Codanin-1 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T626.2 Q8T626

    Gene LinkOut

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