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    vilya [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31264, updated on 4-Jul-2024

    Summary

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    Official Symbol
    vilyaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283545
    Locus tag
    Dmel_CG2709
    See related
    AllianceGenome:FB:FBgn0283545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2709; Dmel\CG2709; EG:95B7.5; mei-826; Vilya
    Summary
    Predicted to enable SUMO transferase activity. Involved in female meiotic nuclear division and positive regulation of meiotic DNA double-strand break formation. Located in central element; recombination nodule; and site of double-strand break. Orthologous to human RNF212B (ring finger protein 212B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See vilya in Genome Data Viewer
    Location:
    3B3-3B3; 1-1.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2726678..2727568)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2620740..2621522)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene female sterile (1) Yb Neighboring gene female sterile (1) Young arrest Neighboring gene deformed wings Neighboring gene tiny tim 50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure. Gershoni M, et al. HGG Adv, 2023 Jul 13. PMID 37124137, Free PMC Article
    2. X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance. Billmyre KK, et al. Proc Natl Acad Sci U S A, 2019 Oct 22. PMID 31570610, Free PMC Article
    3. Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity. Zhaunova L, et al. PLoS Genet, 2016 Aug. PMID 27494704, Free PMC Article
    4. Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster. Lake CM, et al. PLoS Genet, 2019 Jan. PMID 30615609, Free PMC Article
    5. Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila. Lake CM, et al. Elife, 2015 Oct 9. PMID 26452093, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SUMO transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of meiotic DNA double-strand break formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in central element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recombination nodule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vilya
    Names
    CG2709-PA
    meiotic 826
    vilya-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2726678..2727568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130670.2 → NP_570026.1  vilya [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570026.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76908
      Related
      FBpp0070464
      Conserved Domains (2) summary
      pfam11500
      Location:112 → 170
      Cut12; Spindle pole body formation-associated protein
      pfam14634
      Location:20 → 70
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76908.1 O76908

    Gene LinkOut

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