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    asun asunder [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41971, updated on 18-Sep-2024

    Summary

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    Official Symbol
    asunprovided by FlyBase
    Official Full Name
    asunderprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020407
    Locus tag
    Dmel_CG6814
    See related
    AllianceGenome:FB:FBgn0020407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Asu; Asun; ASUN; CG6814; Dmel\CG6814; IntS13; Mat89Bb
    Summary
    Involved in several processes, including flagellated sperm motility; gamete generation; and posterior mRNA localization involved in anterior/posterior axis specification. Located in cytoplasm and nucleus. Part of integrator complex. Is expressed in follicle cell; nurse cell; oocyte; ovary; and testis. Orthologous to human INTS13 (integrator complex subunit 13). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See asun in Genome Data Viewer
    Location:
    89B9-89B9; 3-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16264271..16266891)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12089993..12092613)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene taranis Neighboring gene belphegor Neighboring gene Mst89B Neighboring gene Maternal transcript 89Ba Neighboring gene gilgamesh

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions. Lee LA, et al. Genes Dev, 2003 Dec 1. PMID 14665672, Free PMC Article
    2. A testis-specifically expressed gene is embedded within a cluster of maternally expressed genes at 89B in Drosophila melanogaster. Stebbings L, et al. Dev Genes Evol, 1998 Nov. PMID 9799434
    3. Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis. Sitaram P, et al. Development, 2012 Aug. PMID 22764052, Free PMC Article
    4. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Lee LA, et al. Dev Cell, 2005 Mar. PMID 15737938
    5. asunder is required for dynein localization and dorsal fate determination during Drosophila oogenesis. Sitaram P, et al. Dev Biol, 2014 Feb 1. PMID 24333177, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ASUN is identified as a functional component of Integrator (INT), a multisubunit complex required for 3'-end processing of small nuclear RNAs.
      Title: Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex.
    2. asun is a critical regulator of dynein localization and dynein-mediated processes during Drosophila oogenesis
      Title: asunder is required for dynein localization and dorsal fate determination during Drosophila oogenesis.
    3. Functional and biochemical experiments revealed that Asunder and CG4785 are additional core members of the Integrator complex.
      Title: An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation.
    4. asunder(previously Mat89Bb)required for male fertility; asun spermatocytes & spermatids exhibit reduction of perinuclear dynein-dynactin; model proposed in which asun coordinates spermatogenesis by promoting dynein-dynactin recruitment to nuclear surface
      Title: Asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte nucleus localization involved in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in posterior mRNA localization involved in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    asunder
    Names
    CG6814-PA
    asun-PA
    integrator 13
    maternal transcript 89Bb

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16264271..16266891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079655.4 → NP_524379.2  asunder [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524379.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27924, Q7JP08, Q9VEX5
      Related
      FBpp0082713
      Conserved Domains (1) summary
      pfam10221
      Location:5 → 665
      DUF2151; Cell cycle and development regulator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEX5.1 Q9VEX5

    Gene LinkOut

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