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    Bcs1 Bcs1 chaperone [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34360, updated on 10-May-2024

    Summary

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    Official Symbol
    Bcs1provided by FlyBase
    Official Full Name
    Bcs1 chaperoneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032195
    Locus tag
    Dmel_CG4908
    See related
    AllianceGenome:FB:FBgn0032195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4908; Dmel\CG4908
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in mitochondrial respiratory chain complex III assembly and protein insertion into mitochondrial inner membrane from matrix. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; and endoderm. Human ortholog(s) of this gene implicated in Bjornstad syndrome; GRACILE syndrome; and mitochondrial complex III deficiency nuclear type 1. Orthologous to human BCS1L (BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Bcs1 in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10222657..10224447)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10222657..10224447)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Niemann-Pick type C-1a Neighboring gene Proteasome alpha6 subunit Neighboring gene uncharacterized protein Neighboring gene ovaries absent

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Measurement of mitochondrial respiratory chain enzymatic activities in Drosophila melanogaster samples. Brischigliaro M, et al. STAR Protoc, 2022 Jun 17. PMID 35479112, Free PMC Article
    2. Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster. Brischigliaro M, et al. J Mol Med (Berl), 2021 Oct. PMID 34274978, Free PMC Article
    3. EGCG ameliorates neuronal and behavioral defects by remodeling gut microbiota and TotM expression in Drosophila models of Parkinson's disease. Xu Y, et al. FASEB J, 2020 Apr. PMID 32157731
    4. PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix. Thomas RE, et al. PLoS Genet, 2014. PMID 24874806, Free PMC Article
    5. Drosophila nucleostemin 3 is required to maintain larval neuroblast proliferation. Johnson PW, et al. Dev Biol, 2018 Aug 1. PMID 29679561, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables mitochondrial protein-transporting ATPase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane from matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane from matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane from matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bcs1 chaperone
    Names
    Bcs1-PA
    Bcs1-PB
    CG4908-PA
    CG4908-PB
    NP_609358.1
    NP_723532.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10222657..10224447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164892.2 → NP_723532.1  Bcs1 chaperone, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1EHJ2, Q9VL22
      Related
      FBpp0079540
      Conserved Domains (2) summary
      smart01024
      Location:23 → 192
      BCS1_N; This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein
      cd19510
      Location:202 → 354
      RecA-like_BCS1; Mitochondrial chaperone BCS1

    2. NM_135514.3 → NP_609358.1  Bcs1 chaperone, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1EHJ2, Q9VL22
      Related
      FBpp0079539
      Conserved Domains (2) summary
      smart01024
      Location:23 → 192
      BCS1_N; This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein
      cd19510
      Location:202 → 354
      RecA-like_BCS1; Mitochondrial chaperone BCS1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL22 Q9VL22

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