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    vis vismay [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36372, updated on 5-May-2024

    Summary

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    Official Symbol
    visprovided by FlyBase
    Official Full Name
    vismayprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033748
    Locus tag
    Dmel_CG8821
    See related
    AllianceGenome:FB:FBgn0033748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    achi/vis; CG8821; Dmel\CG8821; dTGIFa; TGIFa; zaa
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription, DNA-templated and spermatogenesis. Located in nucleus. Is expressed in several structures, including gonad and wing disc. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to several human genes including TGIF1 (TGFB induced factor homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See vis in Genome Data Viewer
    Location:
    49A10-49A10; 2-67 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12507896..12510615, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8395401..8398120, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Diuretic hormone 44 receptor 2 Neighboring gene uncharacterized protein Neighboring gene fused lobes Neighboring gene stanley-cup Neighboring gene achintya Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. Xia S, et al. PLoS Genet, 2021 Jul. PMID 34242211, Free PMC Article
    2. Drosophila TGIF proteins are transcriptional activators. Hyman CA, et al. Mol Cell Biol, 2003 Dec. PMID 14645536, Free PMC Article
    3. Dynamics and stage-specificity of between-population gene expression divergence in the Drosophila melanogaster larval fat body. Glaser-Schmitt A, et al. PLoS Genet, 2023 Apr. PMID 37099612, Free PMC Article
    4. On the Regulatory Evolution of New Genes Throughout Their Life History. Zhang JY, et al. Mol Biol Evol, 2019 Jan 1. PMID 30395322
    5. Perceived sperm competition intensity influences seminal fluid protein production prior to courtship and mating. Fedorka KM, et al. Evolution, 2011 Feb. PMID 21271997

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vismay
    Names
    CG8821-PA
    CG8821-PB
    achi/vis
    vis-PA
    vis-PB
    zuker-aly-like a

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12507896..12510615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078990.3 → NP_523714.2  vismay, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523714.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K380
      Related
      FBpp0087055
      Conserved Domains (1) summary
      pfam05920
      Location:109 → 148
      Homeobox_KN; Homeobox KN domain

    2. NM_176157.2 → NP_788337.1  vismay, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788337.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z913
      Related
      FBpp0087056
      Conserved Domains (1) summary
      pfam05920
      Location:109 → 148
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z913 A1Z913
    Q7K380 Q7K380

    Gene LinkOut

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