Hacl1 2-hydroxyacyl-CoA lyase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hacl1provided by MGI
Official Full Name: 2-hydroxyacyl-CoA lyase 1provided by MGI
Primary source: MGI:MGI:1929657
See related: Ensembl:ENSMUSG00000021884 AllianceGenome:MGI:1929657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hpcl; Phyh2; 1600020H07Rik
Summary: Enables carbon-carbon lyase activity. Involved in fatty acid alpha-oxidation. Acts upstream of or within lipid metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in peroxisome. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 112.3), liver E18 (RPKM 83.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 19.23 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (31329183..31364201, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (31607226..31640965, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of omega-Oxidation.
Title: Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation.
Hacl1 plays a significant role in the liver and plasma levels of C17:0, providing evidence it can be endogenously biosynthesized via alpha-oxidation
Title: Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid.
2-hydroxyphytanoyl-CoA lyase has a role in the breakdown of long chain 2-hydroxyfatty acids
Title: Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-hydroxyacyl-CoA lyase activity	ISO Inferred from Sequence Orthology more info
enables 2-hydroxyphytanoyl-CoA lyase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables carbon-carbon lyase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carbon-carbon lyase activity	ISO Inferred from Sequence Orthology more info
enables carbon-carbon lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables thiamine pyrophosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables thiamine pyrophosphate binding	ISO Inferred from Sequence Orthology more info
enables thiamine pyrophosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid alpha-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid alpha-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid alpha-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid alpha-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in methyl-branched fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in methyl-branched fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phytanic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phytanic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to peroxisome	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to peroxisome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: 2-hydroxyacyl-CoA lyase 1

Names: 2-HPCL; 2-hydroxyphytanoyl-CoA lyase; phytanoyl-CoA 2-hydroxylase 2

NP_064359.2

EC 4.1.2.63

XP_036014660.1

EC 4.1.2.63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019975.3 → NP_064359.2 2-hydroxyacyl-CoA lyase 1

See identical proteins and their annotated locations for NP_064359.2

Status: VALIDATED

Source sequence(s)

AK041686, BY340097

Consensus CDS

CCDS26915.1

UniProtKB/Swiss-Prot

Q543K1, Q9DAV1, Q9QXE0

UniProtKB/TrEMBL

D3YZ54

Related

ENSMUSP00000022437.9, ENSMUST00000022437.16

Conserved Domains (4) summary

cd07035
Location:22 → 175

TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins

PRK09259
Location:19 → 564

PRK09259; putative oxalyl-CoA decarboxylase; Validated

cd02004
Location:380 → 563

TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...

pfam00205
Location:208 → 335

TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

31329183..31364201 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158767.1 → XP_036014660.1 2-hydroxyacyl-CoA lyase 1 isoform X1

UniProtKB/TrEMBL

D3YZ54

Conserved Domains (1) summary

PRK09259
Location:19 → 555

PRK09259; putative oxalyl-CoA decarboxylase; Validated