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    Asrgl1 asparaginase like 1 [ Mus musculus (house mouse) ]

    Gene ID: 66514, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Asrgl1provided by MGI
    Official Full Name
    asparaginase like 1provided by MGI
    Primary source
    MGI:MGI:1913764
    See related
    Ensembl:ENSMUSG00000024654 AllianceGenome:MGI:1913764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALP; ALP1; 2410004D18Rik
    Summary
    Predicted to enable asparaginase activity and beta-aspartyl-peptidase activity. Predicted to be involved in asparagine catabolic process via L-aspartate. Located in photoreceptor inner segment. Is expressed in alimentary system; cranium; nervous system; and respiratory system. Orthologous to human ASRGL1 (asparaginase and isoaspartyl peptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 166.3), frontal lobe adult (RPKM 27.7) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asrgl1 in Genome Data Viewer
    Location:
    19 A; 19 6.06 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (9089083..9112930, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (9111719..9135566, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene secretoglobin, family 1A, member 1 Neighboring gene STARR-seq mESC enhancer starr_45516 Neighboring gene predicted gene, 41805 Neighboring gene STARR-seq mESC enhancer starr_45518 Neighboring gene predicted gene, 38656 Neighboring gene ribosomal protein S7 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1 (Asrgl1) Develops Early Onset Retinal Degeneration (RD) Recapitulating the Human Phenotype. Biswas P, et al. Genes (Basel), 2022 Aug 17. PMID 36011372, Free PMC Article
    2. Deletion of Asrgl1 Leads to Photoreceptor Degeneration in Mice. Zhou Y, et al. Front Cell Dev Biol, 2021. PMID 35118070, Free PMC Article
    3. A missense mutation in ASRGL1 is involved in causing autosomal recessive retinal degeneration. Biswas P, et al. Hum Mol Genet, 2016 Jun 15. PMID 27106100, Free PMC Article
    4. The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation. Kadlec L, et al. Proc Natl Acad Sci U S A, 1997 Nov 11. PMID 9356459, Free PMC Article
    5. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1 (Asrgl1) Develops Early Onset Retinal Degeneration (RD) Recapitulating the Human Phenotype.
      Title: A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1 (Asrgl1) Develops Early Onset Retinal Degeneration (RD) Recapitulating the Human Phenotype.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables asparaginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparaginase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables asparaginase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables beta-aspartyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-aspartyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-aspartyl-peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparagine catabolic process via L-aspartate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within asparagine catabolic process via L-aspartate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asparagine catabolic process via L-aspartate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asparagine catabolic process via L-aspartate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isoaspartyl peptidase/L-asparaginase
    Names
    L-asparaginase
    L-asparagine amidohydrolase
    asparaginase-like protein 1
    beta-aspartyl-peptidase
    isoaspartyl dipeptidase
    NP_079886.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025610.3 → NP_079886.2  isoaspartyl peptidase/L-asparaginase

      See identical proteins and their annotated locations for NP_079886.2

      Status: PROVISIONAL

      Source sequence(s)
      AK030209
      Consensus CDS
      CCDS29566.1
      UniProtKB/Swiss-Prot
      Q8C0M9, Q91WC8, Q9CVX3
      Related
      ENSMUSP00000051709.5, ENSMUST00000049948.6
      Conserved Domains (2) summary
      PRK10226
      Location:21 → 300
      PRK10226; isoaspartyl peptidase; Provisional
      cd04702
      Location:19 → 308
      ASRGL1_like; Metazoan L-Asparaginase type 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      9089083..9112930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0M9.1 GenPept UniProtKB/Swiss-Prot:Q8C0M9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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