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    Sh3bp5 SH3-domain binding protein 5 (BTK-associated) [ Mus musculus (house mouse) ]

    Gene ID: 24056, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sh3bp5provided by MGI
    Official Full Name
    SH3-domain binding protein 5 (BTK-associated)provided by MGI
    Primary source
    MGI:MGI:1344391
    See related
    Ensembl:ENSMUSG00000021892 AllianceGenome:MGI:1344391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sab; SH3BP-5
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasmic vesicle membrane; mitochondrion; and nuclear body. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SH3BP5 (SH3 domain binding protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 46.1), CNS E14 (RPKM 37.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sh3bp5 in Genome Data Viewer
    Location:
    14 19.11 cM; 14 B
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31094571..31158056, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31372614..31436100, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene STARR-positive B cell enhancer ABC_E10823 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32149566-32149675 Neighboring gene calpain 7 Neighboring gene STARR-seq mESC enhancer starr_36314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:32229701-32230002 Neighboring gene predicted gene, 35907 Neighboring gene STARR-positive B cell enhancer ABC_E7303 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene methyltransferase 6, methylcytidine Neighboring gene STARR-seq mESC enhancer starr_36316 Neighboring gene ELL associated factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Win S, et al. Hepatology, 2021 Dec. PMID 34331779, Free PMC Article
    2. Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization. Baba Y, et al. Cytogenet Cell Genet, 1999. PMID 10702676
    3. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Win S, et al. Cell Death Dis, 2014 Jan 9. PMID 24407242, Free PMC Article
    4. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. Win S, et al. J Hepatol, 2015 Jun. PMID 25666017, Free PMC Article
    5. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Win S, et al. Hepatology, 2016 Jun. PMID 26845758, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
      Title: Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.
    2. SAB expression levels determine the severity of JNK1-dependent liver injury
      Title: Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.
    3. The binding to and phosphorylation of Sab by p-JNK on the outer mitochondrial membrane leads to SHP1-dependent and DOK4-dependent inactivation of p-Src on the inner membrane; inactivation of mitochondrial Src inhibits electron transport and increases reactive oxygen species release, which sustains JNK activation and promotes cell death and organ injury.
      Title: c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.
    4. The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis.
      Title: Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
    5. ER stress triggers an interaction of JNK with mitochondrial Sab, which leads to impaired respiration and increased mitochondrial reactive oxygen species.
      Title: JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.
    6. SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs).
      Title: SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.
    7. JNK-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
      Title: c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-binding protein 5
    Names
    SH3 domain-binding protein that preferentially associates with BTK

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347585.2 → NP_001334514.1  SH3 domain-binding protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616
      Consensus CDS
      CCDS84108.1
      UniProtKB/Swiss-Prot
      Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
      Related
      ENSMUSP00000098296.4, ENSMUST00000100730.10

    2. NM_001404586.1 → NP_001391515.1  SH3 domain-binding protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616

    3. NM_001404587.1 → NP_001391516.1  SH3 domain-binding protein 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616

    4. NM_001404588.1 → NP_001391517.1  SH3 domain-binding protein 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616

    5. NM_001404589.1 → NP_001391518.1  SH3 domain-binding protein 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616

    6. NM_011894.4 → NP_036024.2  SH3 domain-binding protein 5 isoform 1

      See identical proteins and their annotated locations for NP_036024.2

      Status: VALIDATED

      Source sequence(s)
      AC108416, AC154616
      Consensus CDS
      CCDS36855.1
      UniProtKB/Swiss-Prot
      Q3TTD6, Q8C903, Q8VCZ0, Q9Z131
      Related
      ENSMUSP00000089517.5, ENSMUST00000091903.5
      Conserved Domains (1) summary
      pfam05276
      Location:44 → 270
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31094571..31158056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247814.1 → XP_030103674.1  SH3 domain-binding protein 5 isoform X1

      Conserved Domains (1) summary
      pfam05276
      Location:1 → 112
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    2. XM_030247815.1 → XP_030103675.1  SH3 domain-binding protein 5 isoform X1

      Conserved Domains (1) summary
      pfam05276
      Location:1 → 112
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z131.3 GenPept UniProtKB/Swiss-Prot:Q9Z131

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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