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    Ticrr TOPBP1-interacting checkpoint and replication regulator [ Mus musculus (house mouse) ]

    Gene ID: 77011, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ticrrprovided by MGI
    Official Full Name
    TOPBP1-interacting checkpoint and replication regulatorprovided by MGI
    Primary source
    MGI:MGI:1924261
    See related
    Ensembl:ENSMUSG00000046591 AllianceGenome:MGI:1924261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrrk1; 5730590G19Rik
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including DNA metabolic process; mitotic G2/M transition checkpoint; and response to ionizing radiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain ventricular layer and inferior colliculus. Orthologous to human TICRR (TOPBP1 interacting checkpoint and replication regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.1), thymus adult (RPKM 2.9) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ticrr in Genome Data Viewer
    Location:
    7 D2; 7 45.09 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79309944..79347896)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79660196..79698148)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Rhesus blood group-associated C glycoprotein Neighboring gene cullin 4B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10444 Neighboring gene STARR-seq mESC enhancer starr_19286 Neighboring gene STARR-positive B cell enhancer ABC_E551 Neighboring gene uncharacterized LOC118567517 Neighboring gene kinesin family member 7 Neighboring gene STARR-positive B cell enhancer mm9_chr7:86873152-86873453 Neighboring gene perilipin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities. Pons S, et al. J Mol Cell Cardiol, 2013 Jan. PMID 23201226
    2. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Sansam CL, et al. Genes Dev, 2010 Jan 15. PMID 20080954, Free PMC Article
    3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    treslin
    Names
    leucine-rich repeat kinase 1
    topBP1-interacting, replication-stimulating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029835.1 → NP_084111.1  treslin

      See identical proteins and their annotated locations for NP_084111.1

      Status: VALIDATED

      Source sequence(s)
      AK033104, AK041726, AK051639, BC028450, BC058634, BY731867, CF730550, CN537331
      Consensus CDS
      CCDS21384.1
      UniProtKB/Swiss-Prot
      B2RY55, Q8BQ33, Q8C9N4, Q8CCI2
      Related
      ENSMUSP00000041377.8, ENSMUST00000035977.9
      Conserved Domains (1) summary
      pfam15292
      Location:211 → 1005
      Treslin_N; Treslin N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79309944..79347896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173790.3: Suppressed sequence

      Description
      NM_173790.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQ33.2 GenPept UniProtKB/Swiss-Prot:Q8BQ33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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