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    Zfp532 zinc finger protein 532 [ Mus musculus (house mouse) ]

    Gene ID: 328977, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp532provided by MGI
    Official Full Name
    zinc finger protein 532provided by MGI
    Primary source
    MGI:MGI:3036282
    See related
    Ensembl:ENSMUSG00000042439 AllianceGenome:MGI:3036282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf532; mKIAA1629; C530030I18Rik
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in nucleus. Is expressed in central nervous system; female reproductive system; and urinary system. Orthologous to human ZNF532 (zinc finger protein 532). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 12.0), whole brain E14.5 (RPKM 12.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp532 in Genome Data Viewer
    Location:
    18 E1; 18 38.91 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (65713301..65822514)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (65580230..65689443)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568360 Neighboring gene predicted gene, 41759 Neighboring gene STARR-seq mESC enhancer starr_44834 Neighboring gene STARR-seq mESC enhancer starr_44835 Neighboring gene STARR-seq mESC enhancer starr_44838 Neighboring gene zinc finger protein 592 pseudogene Neighboring gene O-acyltransferase like Neighboring gene predicted gene, 54022

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CircZNF532 knockdown protects retinal pigment epithelial cells against high glucose-induced apoptosis and pyroptosis by regulating the miR-20b-5p/STAT3 axis. Liang GH, et al. J Diabetes Investig, 2022 May. PMID 34839589, Free PMC Article
    2. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircZNF532 knockdown protects retinal pigment epithelial cells against high glucose-induced apoptosis and pyroptosis by regulating the miR-20b-5p/STAT3 axis.
      Title: CircZNF532 knockdown protects retinal pigment epithelial cells against high glucose-induced apoptosis and pyroptosis by regulating the miR-20b-5p/STAT3 axis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 532

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361051.1 → NP_001347980.1  zinc finger protein 532 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124578, AC132307
      Consensus CDS
      CCDS89265.1
      UniProtKB/TrEMBL
      S4R2I9
      Conserved Domains (3) summary
      sd00017
      Location:1024 → 1044
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16622
      Location:1202 → 1230
      zf-C2H2_11; zinc-finger C2H2-type
      cl25756
      Location:150 → 360
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    2. NM_001361052.1 → NP_001347981.1  zinc finger protein 532 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124578, AC132307
      Consensus CDS
      CCDS89265.1
      UniProtKB/TrEMBL
      S4R2I9
      Conserved Domains (3) summary
      sd00017
      Location:1024 → 1044
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16622
      Location:1202 → 1230
      zf-C2H2_11; zinc-finger C2H2-type
      cl25756
      Location:150 → 360
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    3. NM_001361053.1 → NP_001347982.1  zinc finger protein 532 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC124578, AC132307
      Consensus CDS
      CCDS89265.1
      UniProtKB/TrEMBL
      S4R2I9
      Related
      ENSMUSP00000157481.2, ENSMUST00000237553.2
      Conserved Domains (3) summary
      sd00017
      Location:1024 → 1044
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16622
      Location:1202 → 1230
      zf-C2H2_11; zinc-finger C2H2-type
      cl25756
      Location:150 → 360
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    4. NM_207255.2 → NP_997138.1  zinc finger protein 532 isoform 2

      See identical proteins and their annotated locations for NP_997138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AA253972, AK163498, AK163988, BC067032
      Consensus CDS
      CCDS29307.1
      UniProtKB/Swiss-Prot
      Q504Z6, Q6NXK2, Q6ZPL1
      Related
      ENSMUSP00000036582.5, ENSMUST00000049016.12
      Conserved Domains (3) summary
      sd00017
      Location:753 → 772
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13912
      Location:999 → 1021
      zf-C2H2_6; C2H2-type zinc finger
      pfam16622
      Location:934 → 962
      zf-C2H2_11; zinc-finger C2H2-type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      65713301..65822514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXK2.1 GenPept UniProtKB/Swiss-Prot:Q6NXK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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