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    Alpk2 alpha-kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 225638, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Alpk2provided by MGI
    Official Full Name
    alpha-kinase 2provided by MGI
    Primary source
    MGI:MGI:2449492
    See related
    Ensembl:ENSMUSG00000032845 AllianceGenome:MGI:2449492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hak; Gm549
    Summary
    Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to be involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Predicted to act upstream of or within regulation of gene expression. Predicted to colocalize with basolateral plasma membrane. Orthologous to human ALPK2 (alpha kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 10.5) and mammary gland adult (RPKM 0.7) See more
    Orthologs
    human all
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    Genomic context

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    See Alpk2 in Genome Data Viewer
    Location:
    18 E1; 18 38.41 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (65398600..65526959, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (65265529..65393888, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene neural precursor cell expressed, developmentally down-regulated gene 4-like Neighboring gene STARR-seq mESC enhancer starr_44819 Neighboring gene predicted gene, 41756 Neighboring gene STARR-seq mESC enhancer starr_44820 Neighboring gene uncharacterized LOC118568359 Neighboring gene STARR-positive B cell enhancer ABC_E9983 Neighboring gene STARR-seq mESC enhancer starr_44824 Neighboring gene microRNA 122 Neighboring gene STARR-positive B cell enhancer ABC_E3231 Neighboring gene STARR-positive B cell enhancer ABC_E2511 Neighboring gene STARR-positive B cell enhancer ABC_E7595 Neighboring gene STARR-seq mESC enhancer starr_44825 Neighboring gene predicted gene, 41757 Neighboring gene STARR-positive B cell enhancer ABC_E7596 Neighboring gene STARR-seq mESC enhancer starr_44826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:65590163-65590272 Neighboring gene STARR-positive B cell enhancer mm9_chr18:65590289-65590590 Neighboring gene predicted gene, 46618 Neighboring gene MALT1 paracaspase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Atypical ALPK2 kinase is not essential for cardiac development and function. Bogomolovas J, et al. Am J Physiol Heart Circ Physiol, 2020 Jun 1. PMID 32383995, Free PMC Article
    2. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Ryazanov AG, et al. Curr Biol, 1999 Jan 28. PMID 10021370
    3. The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Budry L, et al. Genes Dev, 2012 Oct 15. PMID 23070814, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epicardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epicardium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway involved in heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway involved in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alpha-protein kinase 2
    Names
    heart alpha-kinase
    heart alpha-protein kinase
    NP_001032371.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037294.1 → NP_001032371.1  alpha-protein kinase 2

      See identical proteins and their annotated locations for NP_001032371.1

      Status: VALIDATED

      Source sequence(s)
      AC157910
      Consensus CDS
      CCDS50310.1
      UniProtKB/Swiss-Prot
      E9QL35, Q91ZB0
      Related
      ENSMUSP00000048752.8, ENSMUST00000035548.16
      Conserved Domains (4) summary
      cd00096
      Location:29 → 101
      Ig; Immunoglobulin domain
      smart00410
      Location:1775 → 1847
      IG_like; Immunoglobulin like
      smart00811
      Location:1879 → 2098
      Alpha_kinase; Alpha-kinase family
      pfam07679
      Location:14 → 104
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      65398600..65526959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZB0.3 GenPept UniProtKB/Swiss-Prot:Q91ZB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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