C1qtnf3 C1q and tumor necrosis factor related protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C1qtnf3provided by MGI
Official Full Name: C1q and tumor necrosis factor related protein 3provided by MGI
Primary source: MGI:MGI:1932136
See related: Ensembl:ENSMUSG00000058914 AllianceGenome:MGI:1932136
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adim; Cors; CTRP3; Corcs; CORS26; CORS-26; 2310005P21Rik
Summary: Enables identical protein binding activity. Involved in positive regulation of adiponectin secretion and positive regulation of cytokine production. Acts upstream of or within glucose homeostasis; negative regulation of gluconeogenesis; and positive regulation of intracellular signal transduction. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including central nervous system; epithelium; jaw; metanephros; and musculoskeletal system. Orthologous to human C1QTNF3 (C1q and TNF related 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 35.7), subcutaneous fat pad adult (RPKM 12.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 5.38 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (10952418..10980248)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (10952119..10980162)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gCTRP3 inhibits oophorectomy-induced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice.
Title: gCTRP3 inhibits oophorectomy‑induced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice.
CTRP3 regulates NF-kappaB and TGFbeta1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA.
Title: CTRP3 regulates NF-κB and TGFβ1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA.
CTRP3 promotes TNF-alpha-induced apoptosis and barrier dysfunction in salivary epithelial cells.
Title: CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells.
CTRP3 alleviates myocardial ischemia/reperfusion injury in mice through activating LAMP1/JIP2/JNK pathway.
Title: CTRP3 alleviates myocardial ischemia/reperfusion injury in mice through activating LAMP1/JIP2/JNK pathway.
Adipocyte-Derived CTRP3 Exhibits Anti-Inflammatory Effects via LAMP1-STAT3 Axis in Psoriasis.
Title: Adipocyte-Derived CTRP3 Exhibits Anti-Inflammatory Effects via LAMP1-STAT3 Axis in Psoriasis.
CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue.
Title: CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue.
C1q/tumor necrosis factor-related protein-3 acts as a target treating hepatic fibrosis.
Title: C1q/tumor necrosis factor-related protein-3 acts as a target treating hepatic fibrosis.
The adipokine C1q/TNF-related protein-3 (CTRP-3) inhibits Toll-like receptor (TLR)-induced expression of Cathelicidin antimicrobial peptide (CAMP) in adipocytes.
Title: The adipokine C1q/TNF-related protein-3 (CTRP-3) inhibits Toll-like receptor (TLR)-induced expression of Cathelicidin antimicrobial peptide (CAMP) in adipocytes.
Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice.
Title: Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice.
The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation.
Title: The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of adiponectin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of adiponectin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: complement C1q tumor necrosis factor-related protein 3

Names: adiponectin m; cartducin; cartonectin; collagenous repeat-containing sequence 26 kDa protein; secretory protein CORS26

NP_001191063.1

EC 5.1.99.4

NP_112150.1

EC 5.1.99.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204134.1 → NP_001191063.1 complement C1q tumor necrosis factor-related protein 3 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC102219

Consensus CDS

CCDS56977.1

UniProtKB/TrEMBL

D3YZ61

Related

ENSMUSP00000106152.2, ENSMUST00000110523.2

Conserved Domains (2) summary

pfam00386
Location:192 → 315

C1q; C1q domain

pfam01391
Location:147 → 186

Collagen; Collagen triple helix repeat (20 copies)
NM_030888.4 → NP_112150.1 complement C1q tumor necrosis factor-related protein 3 isoform 2 precursor

See identical proteins and their annotated locations for NP_112150.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC102219, AK029352

Consensus CDS

CCDS27380.1

UniProtKB/Swiss-Prot

Q9ES30

UniProtKB/TrEMBL

Q4ZJN6

Related

ENSMUSP00000022853.9, ENSMUST00000022853.15

Conserved Domains (2) summary

pfam01391
Location:71 → 113

Collagen; Collagen triple helix repeat (20 copies)

pfam00386
Location:119 → 242

C1q; C1q domain