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    CKS2 CDC28 protein kinase regulatory subunit 2 [ Homo sapiens (human) ]

    Gene ID: 1164, updated on 28-Oct-2024

    Summary

    Official Symbol
    CKS2provided by HGNC
    Official Full Name
    CDC28 protein kinase regulatory subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:2000
    See related
    Ensembl:ENSG00000123975 MIM:116901; AllianceGenome:HGNC:2000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKSHS2
    Summary
    CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 88.8), bone marrow (RPKM 46.4) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CKS2 in Genome Data Viewer
    Location:
    9q22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (89311195..89316703)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (101474973..101480477)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91926110..91931618)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91652935-91653434 Neighboring gene SHC adaptor protein 3 Neighboring gene negCOR silencer S5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91787594-91788094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91788095-91788595 Neighboring gene Sharpr-MPRA regulatory region 4063 Neighboring gene uncharacterized LOC105376136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:91896966-91897484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20005 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20007 Neighboring gene microRNA 3153 Neighboring gene SECIS binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91978812-91979312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:91979313-91979813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28531 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108523 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108535 Neighboring gene semaphorin 4D Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92020317-92021138 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92021139-92021959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:92026366-92026868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:92026869-92027370 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:92027622-92028122 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:92028123-92028623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28537 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92040313-92041172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28543 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:92046837-92047618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92049183-92049964 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92049965-92050746 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92050747-92051528 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92051529-92052310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92054729-92055306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:92057617-92058192 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108605 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92061728-92062338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:92064045-92064893 Neighboring gene proliferation-associated 2G4 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiosis I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinases regulatory subunit 2
    Names
    CDC28 protein kinase 2
    CKS-2
    CKS1(S. cerevisiae Cdc28/Cdc2 kinase subunit) homolog-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001827.3NP_001818.1  cyclin-dependent kinases regulatory subunit 2

      See identical proteins and their annotated locations for NP_001818.1

      Status: REVIEWED

      Source sequence(s)
      BM838320, BM841681, X54942
      Consensus CDS
      CCDS6682.1
      UniProtKB/Swiss-Prot
      P33552, Q6FGI9, Q6LET5
      Related
      ENSP00000364976.3, ENST00000314355.7
      Conserved Domains (1) summary
      pfam01111
      Location:873
      CKS; Cyclin-dependent kinase regulatory subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      89311195..89316703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      101474973..101480477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)