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    LIPK lipase family member K [ Homo sapiens (human) ]

    Gene ID: 643414, updated on 28-Oct-2024

    Summary

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    Official Symbol
    LIPKprovided by HGNC
    Official Full Name
    lipase family member Kprovided by HGNC
    Primary source
    HGNC:HGNC:23444
    See related
    Ensembl:ENSG00000204021 MIM:613922; AllianceGenome:HGNC:23444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIPL2; bA186O14.2
    Summary
    Predicted to enable lipoprotein lipase activity. Predicted to be involved in cornification. Predicted to be located in extracellular region. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward skin (RPKM 5.3) See more
    Orthologs
    all
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    Genomic context

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    See LIPK in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88706249..88752776)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89590236..89636775)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90466006..90512533)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase F, gastric type Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:90462586-90463435 Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, gamma pseudogene 1 Neighboring gene keratin 8 pseudogene 38 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:90518932-90520131 Neighboring gene lipase family member N Neighboring gene RCC1 and BTB domain containing protein 2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Large-scale identification of human genes implicated in epidermal barrier function. Toulza E, et al. Genome Biol, 2007. PMID 17562024, Free PMC Article
    2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipoprotein lipase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in cornification TAS
    Traceable Author Statement
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipase member K
    Names
    lipase K
    lipase-like abhydrolase domain-containing protein 2
    lipase-like, ab-hydrolase domain containing 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080518.2 → NP_001073987.1  lipase member K isoform 1 precursor

      See identical proteins and their annotated locations for NP_001073987.1

      Status: VALIDATED

      Source sequence(s)
      AL358532
      Consensus CDS
      CCDS44455.1
      UniProtKB/Swiss-Prot
      A7KIH8, Q5VXJ0
      Related
      ENSP00000383900.1, ENST00000404190.3
      Conserved Domains (3) summary
      PLN02872
      Location:11 → 390
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:35 → 97
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:79 → 226
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_001378091.1 → NP_001365020.1  lipase member K isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL358532
      Conserved Domains (1) summary
      PLN02872
      Location:11 → 357
      PLN02872; triacylglycerol lipase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      88706249..88752776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540075.2 → XP_011538377.1  lipase member K isoform X2

      Conserved Domains (3) summary
      PLN02872
      Location:20 → 399
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:44 → 106
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:88 → 235
      Abhydrolase_5; Alpha/beta hydrolase family

    2. XM_011540073.4 → XP_011538375.1  lipase member K isoform X1

      Conserved Domains (3) summary
      PLN02872
      Location:31 → 410
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:55 → 117
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:99 → 246
      Abhydrolase_5; Alpha/beta hydrolase family

    3. XM_017016545.2 → XP_016872034.1  lipase member K isoform X3

    4. XM_017016547.3 → XP_016872036.1  lipase member K isoform X5

    5. XM_017016546.3 → XP_016872035.1  lipase member K isoform X4

    6. XM_017016548.3 → XP_016872037.1  lipase member K isoform X6

    7. XM_011540082.2 → XP_011538384.1  lipase member K isoform X7

      Conserved Domains (1) summary
      PLN02872
      Location:7 → 256
      PLN02872; triacylglycerol lipase

    RNA

    1. XR_001747183.3 RNA Sequence

    2. XR_001747184.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      89590236..89636775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366571.1 → XP_054222546.1  lipase member K isoform X2

    2. XM_054366570.1 → XP_054222545.1  lipase member K isoform X1

    3. XM_054366572.1 → XP_054222547.1  lipase member K isoform X3

    4. XM_054366574.1 → XP_054222549.1  lipase member K isoform X5

    5. XM_054366573.1 → XP_054222548.1  lipase member K isoform X4

    6. XM_054366575.1 → XP_054222550.1  lipase member K isoform X6

    7. XM_054366576.1 → XP_054222551.1  lipase member K isoform X7

    RNA

    1. XR_008488249.1 RNA Sequence

    2. XR_008488250.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VXJ0.2 GenPept UniProtKB/Swiss-Prot:Q5VXJ0

    Gene LinkOut

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