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    PROCA1 protein interacting with cyclin A1 [ Homo sapiens (human) ]

    Gene ID: 147011, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PROCA1provided by HGNC
    Official Full Name
    protein interacting with cyclin A1provided by HGNC
    Primary source
    HGNC:HGNC:28600
    See related
    Ensembl:ENSG00000167525 MIM:617376; AllianceGenome:HGNC:28600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables cyclin binding activity. Predicted to be involved in arachidonate secretion and phospholipid metabolic process. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in testis (RPKM 33.9) and spleen (RPKM 1.8) See more
    Orthologs
    mouse all
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    Genomic context

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    See PROCA1 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28703197..28711888, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29645981..29654697, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27030215..27038906, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene stromal cell derived factor 2 Neighboring gene ribosomal protein S12 pseudogene 28 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:26988611-26989810 Neighboring gene SPT6 homolog, histone chaperone and transcription elongation factor Neighboring gene Sharpr-MPRA regulatory region 10516 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:27037571-27038346 and GRCh37_chr17:27038347-27039122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8349 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27045659-27046259 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27046260-27046861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11939 Neighboring gene RAB34, member RAS oncogene family Neighboring gene small nucleolar RNA, C/D box 42B Neighboring gene ribosomal protein L23a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. Diederichs S, et al. J Biol Chem, 2004 Aug 6. PMID 15159402
    2. ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. Noguchi A, et al. Biol Open, 2018 Mar 12. PMID 29449217, Free PMC Article
    3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
    5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC39650

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein PROCA1
    Names
    proline-rich cyclin A1-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304949.2 → NP_001291878.1  protein PROCA1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AI797917, BC029574, CR984201, HY044209
      UniProtKB/Swiss-Prot
      B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
      Conserved Domains (1) summary
      cd04705
      Location:17 → 95
      PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

    2. NM_001304951.2 → NP_001291880.1  protein PROCA1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AI797917, BC029574, BQ215318, HY044209
      UniProtKB/Swiss-Prot
      Q8NCQ7

    3. NM_001304952.2 → NP_001291881.1  protein PROCA1 isoform d

      See identical proteins and their annotated locations for NP_001291881.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' exon structure, and it thus differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AC010761, AI797917, AK301868, BC029574, DB038438
      UniProtKB/Swiss-Prot
      B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
      Conserved Domains (1) summary
      cd04705
      Location:7 → 106
      PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

    4. NM_001304953.2 → NP_001291882.1  protein PROCA1 isoform e

      See identical proteins and their annotated locations for NP_001291882.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal exon but contains a different internal exon, and it also uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a. Variants 5, 6 and 9 encode isoform e.
      Source sequence(s)
      AI797917, BC029574, CD300282, HY044209
      UniProtKB/Swiss-Prot
      Q8NCQ7

    5. NM_001304954.2 → NP_001291883.1  protein PROCA1 isoform e

      See identical proteins and their annotated locations for NP_001291883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains alternate 5' exon structure and it also uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a. Variants 5, 6 and 9 encode isoform e.
      Source sequence(s)
      AC010761, AI797917, AK310299, BC029574, DB038438
      UniProtKB/Swiss-Prot
      Q8NCQ7

    6. NM_001366301.1 → NP_001353230.1  protein PROCA1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC010761
      Consensus CDS
      CCDS92283.1
      UniProtKB/Swiss-Prot
      B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
      UniProtKB/TrEMBL
      A0A804HIV4
      Related
      ENSP00000507242.1, ENST00000682792.1
      Conserved Domains (1) summary
      cd04705
      Location:33 → 132
      PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

    7. NM_001366302.1 → NP_001353231.1  protein PROCA1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC010761
      UniProtKB/Swiss-Prot
      B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
      Conserved Domains (1) summary
      cl05417
      Location:6 → 78
      PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    8. NM_001366303.1 → NP_001353232.1  protein PROCA1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) encodes isoform e. Variants 5, 6 and 9 encode isoform e.
      Source sequence(s)
      AC010761
      Related
      ENST00000674362.1

    9. NM_152465.3 → NP_689678.1  protein PROCA1 isoform b

      See identical proteins and their annotated locations for NP_689678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AI797917, BC029574, HY044209
      Consensus CDS
      CCDS11239.1
      UniProtKB/Swiss-Prot
      B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
      Related
      ENSP00000301039.2, ENST00000301039.6
      Conserved Domains (1) summary
      cd04705
      Location:5 → 104
      PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      28703197..28711888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435477.1 → XP_047291433.1  protein PROCA1 isoform X2

    2. XM_006721723.4 → XP_006721786.1  protein PROCA1 isoform X1

      UniProtKB/Swiss-Prot
      B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
      Conserved Domains (1) summary
      cd04705
      Location:33 → 132
      PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

    3. XM_047435476.1 → XP_047291432.1  protein PROCA1 isoform X2

    4. XM_047435473.1 → XP_047291429.1  protein PROCA1 isoform X2

    5. XM_047435475.1 → XP_047291431.1  protein PROCA1 isoform X2

    6. XM_047435474.1 → XP_047291430.1  protein PROCA1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      29645981..29654697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315232.1 → XP_054171207.1  protein PROCA1 isoform X2

    2. XM_054315227.1 → XP_054171202.1  protein PROCA1 isoform X1

    3. XM_054315231.1 → XP_054171206.1  protein PROCA1 isoform X2

    4. XM_054315228.1 → XP_054171203.1  protein PROCA1 isoform X2

    5. XM_054315230.1 → XP_054171205.1  protein PROCA1 isoform X2

    6. XM_054315229.1 → XP_054171204.1  protein PROCA1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NCQ7.3 GenPept UniProtKB/Swiss-Prot:Q8NCQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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