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    FUT11 fucosyltransferase 11 [ Homo sapiens (human) ]

    Gene ID: 170384, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FUT11provided by HGNC
    Official Full Name
    fucosyltransferase 11provided by HGNC
    Primary source
    HGNC:HGNC:19233
    See related
    Ensembl:ENSG00000196968 MIM:616932; AllianceGenome:HGNC:19233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FUCTXI
    Summary
    Enables fucosyltransferase activity. Involved in N-glycan fucosylation. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Implicated in stomach cancer. Biomarker of stomach cancer. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 8.2), lung (RPKM 6.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FUT11 in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73772276..73780254)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74643692..74651652)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75532034..75535977)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902453 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:75503472-75504671 Neighboring gene SEC24 homolog C, COPII coat complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75532921-75533451 Neighboring gene uncharacterized LOC107984243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3575 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma. Zhang P, et al. Int Immunopharmacol, 2022 Dec. PMID 36403525
    2. FUT11 is a target gene of HIF1α that promotes the progression of hepatocellular carcinoma. Ruan W, et al. Cell Biol Int, 2021 Nov. PMID 34288238
    3. FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data. Zodro E, et al. Tumour Biol, 2014 Mar. PMID 24318988, Free PMC Article
    4. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). Mollicone R, et al. J Biol Chem, 2009 Feb 13. PMID 19088067
    5. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma.
      Title: Dry and wet experiments reveal the significant role of FUT11 in clear cell renal cell carcinoma.
    2. FUT11 is a target gene of HIF1alpha that promotes the progression of hepatocellular carcinoma.
      Title: FUT11 is a target gene of HIF1α that promotes the progression of hepatocellular carcinoma.
    3. FUT11's expression might be potentially used as a biomarker of disease progression in clear cell renal cell carcinoma
      Title: FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data.
    4. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
      Title: Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33202, MGC119338, MGC119339

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-(1,3)-fucosyltransferase 11
    Names
    alpha (1,3) fucosyltransferase
    fuc-TXI
    fucT-XI
    fucosyltransferase XI
    galactoside 3-L-fucosyltransferase 11
    NP_001271123.1
    NP_775811.2
    XP_006717719.1
    XP_047280644.1
    XP_047280645.1
    XP_054220913.1
    XP_054220914.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284194.2 → NP_001271123.1  alpha-(1,3)-fucosyltransferase 11 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001271123.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC022400, BC036037, BC100994
      Consensus CDS
      CCDS60558.1
      UniProtKB/TrEMBL
      B2RC53
      Related
      ENSP00000378270.1, ENST00000394790.2
      Conserved Domains (2) summary
      pfam00852
      Location:216 → 355
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:77 → 176
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. NM_173540.3 → NP_775811.2  alpha-(1,3)-fucosyltransferase 11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_775811.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC022400, BC036037, BC100997
      Consensus CDS
      CCDS7333.1
      UniProtKB/Swiss-Prot
      Q495W5, Q495W7, Q8IYE4
      UniProtKB/TrEMBL
      B2RC53
      Related
      ENSP00000361932.3, ENST00000372841.8
      Conserved Domains (2) summary
      pfam00852
      Location:216 → 355
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:77 → 176
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      73772276..73780254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717656.5 → XP_006717719.1  alpha-(1,3)-fucosyltransferase 11 isoform X1

      UniProtKB/TrEMBL
      B2RC53
      Conserved Domains (2) summary
      pfam00852
      Location:216 → 355
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:77 → 176
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. XM_047424688.1 → XP_047280644.1  alpha-(1,3)-fucosyltransferase 11 isoform X2

    3. XM_047424689.1 → XP_047280645.1  alpha-(1,3)-fucosyltransferase 11 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      74643692..74651652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364938.1 → XP_054220913.1  alpha-(1,3)-fucosyltransferase 11 isoform X1

    2. XM_054364939.1 → XP_054220914.1  alpha-(1,3)-fucosyltransferase 11 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q495W5.1 GenPept UniProtKB/Swiss-Prot:Q495W5

    Gene LinkOut

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