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    LRRC74A leucine rich repeat containing 74A [ Homo sapiens (human) ]

    Gene ID: 145497, updated on 17-Sep-2024

    Summary

    Official Symbol
    LRRC74Aprovided by HGNC
    Official Full Name
    leucine rich repeat containing 74Aprovided by HGNC
    Primary source
    HGNC:HGNC:23346
    See related
    Ensembl:ENSG00000100565 AllianceGenome:HGNC:23346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRRC74; C14orf166B
    Expression
    Restricted expression toward testis (RPKM 2.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LRRC74A in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (76826408..76870304)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (71036112..71080030)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77292751..77336647)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5958 Neighboring gene vasohibin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77241882-77242840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8772 Neighboring gene VASH1 antisense RNA 1 Neighboring gene angel homolog 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77278266-77278840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77278841-77279414 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:77288377-77289157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77294675-77295362 Neighboring gene Sharpr-MPRA regulatory region 2360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77350573-77351390 Neighboring gene RN7SK pseudogene 17 Neighboring gene ribosomal protein L22 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 74A
    Names
    leucine rich repeat containing 74
    leucine-rich repeat-containing protein 74

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385106.1NP_001372035.1  leucine-rich repeat-containing protein 74A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Consensus CDS
      CCDS91911.1
      UniProtKB/TrEMBL
      A0A8I5KUZ3, A0A8I5KW16
      Related
      ENSP00000509938.1, ENST00000689127.1
      Conserved Domains (2) summary
      sd00033
      Location:119141
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:95351
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_001385107.1NP_001372036.1  leucine-rich repeat-containing protein 74A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Conserved Domains (2) summary
      sd00033
      Location:119141
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:95344
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. NM_001385108.1NP_001372037.1  leucine-rich repeat-containing protein 74A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Consensus CDS
      CCDS91912.1
      UniProtKB/TrEMBL
      A0A8I5KUH5
      Related
      ENSP00000509131.1, ENST00000691684.1
      Conserved Domains (2) summary
      sd00033
      Location:119141
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:95307
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. NM_194287.3NP_919263.2  leucine-rich repeat-containing protein 74A isoform 1

      See identical proteins and their annotated locations for NP_919263.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF111169, BC121159, DB337977, DC397584
      Consensus CDS
      CCDS9853.2
      UniProtKB/Swiss-Prot
      Q0VAA2, Q6ZUG6, Q9Y627
      Related
      ENSP00000377369.3, ENST00000393774.7
      Conserved Domains (2) summary
      sd00033
      Location:136158
      LRR_RI; leucine-rich repeat [structural motif]
      cl42388
      Location:112368
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RNA

    1. NR_169572.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Related
      ENST00000484640.6
    2. NR_169573.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Related
      ENST00000216450.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      76826408..76870304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021035.3XP_016876524.1  leucine-rich repeat-containing protein 74A isoform X1

    2. XM_047431012.1XP_047286968.1  leucine-rich repeat-containing protein 74A isoform X2

    3. XM_047431013.1XP_047286969.1  leucine-rich repeat-containing protein 74A isoform X3

    4. XM_047431014.1XP_047286970.1  leucine-rich repeat-containing protein 74A isoform X4

      Related
      ENST00000557453.6
    5. XM_047431015.1XP_047286971.1  leucine-rich repeat-containing protein 74A isoform X6

    6. XM_011536487.2XP_011534789.2  leucine-rich repeat-containing protein 74A isoform X5

    7. XM_047431016.1XP_047286972.1  leucine-rich repeat-containing protein 74A isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      71036112..71080030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375466.1XP_054231441.1  leucine-rich repeat-containing protein 74A isoform X1

    2. XM_054375467.1XP_054231442.1  leucine-rich repeat-containing protein 74A isoform X2

    3. XM_054375468.1XP_054231443.1  leucine-rich repeat-containing protein 74A isoform X3

    4. XM_054375469.1XP_054231444.1  leucine-rich repeat-containing protein 74A isoform X4

    5. XM_054375471.1XP_054231446.1  leucine-rich repeat-containing protein 74A isoform X6

    6. XM_054375470.1XP_054231445.1  leucine-rich repeat-containing protein 74A isoform X5

    7. XM_054375472.1XP_054231447.1  leucine-rich repeat-containing protein 74A isoform X7