Rngtt RNA guanylyltransferase and 5'-phosphatase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rngttprovided by MGI
Official Full Name: RNA guanylyltransferase and 5'-phosphataseprovided by MGI
Primary source: MGI:MGI:1329041
See related: Ensembl:ENSMUSG00000028274 AllianceGenome:MGI:1329041
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HCE; MCE1
Summary: Predicted to enable inorganic triphosphate phosphatase activity and mRNA guanylyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleus. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human RNGTT (RNA guanylyltransferase and 5'-phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.4), CNS E14 (RPKM 2.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 14.78 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (33310300..33502610)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (33310300..33502614)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overall, both in vivo and in vitro studies indicate that the functional domain of Mce1 is between a.a. 211 and 567, and the heptapeptide sequence between 561 and 567 may play an important role in the enzyme activity.
Title: Functional characterization of the C-terminal domain of mouse capping enzyme.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Mit137 (e-PCR), detects polymorphism
- UniSTS:129912

RH136344 (e-PCR)
- UniSTS:210334

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables RNA guanylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables inorganic triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables inorganic triphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 5'-triphosphate monophosphatase activity	IEA Inferred from Electronic Annotation more info
enables mRNA guanylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA guanylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables mRNA guanylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables polynucleotide 5'-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 7-methylguanosine mRNA capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in 7-methylguanosine mRNA capping	ISO Inferred from Sequence Orthology more info
involved_in 7-methylguanosine mRNA capping	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mRNA-capping enzyme

NP_001292202.1

EC 2.7.7.50

EC 3.6.1.74

NP_001413065.1

EC 2.7.7.50

EC 3.6.1.74

NP_001413066.1

EC 2.7.7.50

EC 3.6.1.74

NP_036014.1

EC 2.7.7.50

EC 3.6.1.74

XP_006537952.1

EC 2.7.7.50

EC 3.6.1.74

XP_006537953.1

EC 2.7.7.50

EC 3.6.1.74

XP_011248317.1

EC 2.7.7.50

EC 3.6.1.74

XP_017175678.2

EC 2.7.7.50

EC 3.6.1.74

XP_030109377.1

EC 2.7.7.50

EC 3.6.1.74

XP_036019988.1

EC 2.7.7.50

EC 3.6.1.74

XP_036019989.1

EC 2.7.7.50

EC 3.6.1.74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305273.2 → NP_001292202.1 mRNA-capping enzyme isoform 2

See identical proteins and their annotated locations for NP_001292202.1

Status: VALIDATED

Source sequence(s)

AC093925, AL772272, BX842672

Consensus CDS

CCDS84712.1

UniProtKB/TrEMBL

Q3UCK1, Q9DCC1

Related

ENSMUSP00000029942.8, ENSMUST00000029942.8

Conserved Domains (3) summary

cd07895
Location:248 → 461

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

pfam03919
Location:465 → 545

mRNA_cap_C; mRNA capping enzyme, C-terminal domain

cl21483
Location:47 → 143

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001426136.1 → NP_001413065.1 mRNA-capping enzyme isoform 3

Status: VALIDATED

Source sequence(s)

AC093925, AL772272, BX842672
NM_001426137.1 → NP_001413066.1 mRNA-capping enzyme isoform 4

Status: VALIDATED

Source sequence(s)

AC093925, AL772272, BX842672
NM_011884.4 → NP_036014.1 mRNA-capping enzyme isoform 1

See identical proteins and their annotated locations for NP_036014.1

Status: VALIDATED

Source sequence(s)

AC093925, AL772272, BX842672

Consensus CDS

CCDS38705.1

UniProtKB/Swiss-Prot

O55236

UniProtKB/TrEMBL

Q3UA94, Q3UCK1

Related

ENSMUSP00000103788.3, ENSMUST00000108153.9

Conserved Domains (3) summary

cd07895
Location:248 → 461

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

pfam03919
Location:465 → 558

mRNA_cap_C; mRNA capping enzyme, C-terminal domain

cl21483
Location:47 → 143

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

33310300..33502610

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320189.3 → XP_017175678.2 mRNA-capping enzyme isoform X3

UniProtKB/TrEMBL

Q3TUK6

Conserved Domains (2) summary

cd07895
Location:238 → 451

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

cl28904
Location:45 → 165

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_030253517.1 → XP_030109377.1 mRNA-capping enzyme isoform X7

Conserved Domains (2) summary

cd07895
Location:238 → 414

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

cl28904
Location:45 → 165

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036164096.1 → XP_036019989.1 mRNA-capping enzyme isoform X2

UniProtKB/TrEMBL

Q3TUK6

Conserved Domains (2) summary

cd07895
Location:248 → 461

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

cd17664
Location:9 → 175

Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
XM_036164095.1 → XP_036019988.1 mRNA-capping enzyme isoform X1

UniProtKB/TrEMBL

Q3TUK6

Conserved Domains (2) summary

cd07895
Location:248 → 461

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

cd17664
Location:9 → 175

Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
XM_006537889.5 → XP_006537952.1 mRNA-capping enzyme isoform X4

UniProtKB/TrEMBL

Q3TUK6

Conserved Domains (2) summary

cd07895
Location:248 → 447

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

cd17664
Location:9 → 175

Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
XM_006537890.4 → XP_006537953.1 mRNA-capping enzyme isoform X5

UniProtKB/TrEMBL

Q3TUK6

Conserved Domains (2) summary

cd07895
Location:248 → 456

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

cd17664
Location:9 → 175

Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
XM_011250015.3 → XP_011248317.1 mRNA-capping enzyme isoform X6

UniProtKB/TrEMBL

Q3TUK6

Conserved Domains (2) summary

cd07895
Location:248 → 424

Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes

cd17664
Location:9 → 175

Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme